Moderately to Severely Active Crohn Disease

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Review clinical trials related to Moderately to Severely Active Crohn Disease. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

This study has 3 treatment phases, a 12-Week Induction Phase, a 40-Week Maintenance Phase, and a 48-Week Extension Phase. The objective is to evaluate the efficacy and safety of obefazimod compared to placebo as induction and maintenance therapy in subjects with moderately to severely active CD after inadequate response (no response, loss of response, or intolerance) to conventional therapies and/or advanced therapies. The primary objective for the 48-Week Extension Phase is to evaluate the safety and tolerability of obefazimod compared with placebo in subjects who are enrolled in the Extension Phase.

Participants needed: 212
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Abivax S.A.Updated: Apr 27, 2026Locations: 149
Eligibility criteria

Male or female (at birth) 18 to 75 years old and able to understand, sign, and d... [+7]

WOCBP subject who is pregnant or breast-feeding at screening, or intends to beco... [+42]