Health Trials

MSI-H/dMMR Gastroesophageal-junction Cancer

2

Review clinical trials related to MSI-H/dMMR Gastroesophageal-junction Cancer. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

The goal of this clinical trial is to determine the most effective dose of EIK1005 that a person can take safely. Additionally, this study will test how well EIK1005 is tolerated alone and in combination with pembrolizumab in treating patients with advanced cancer.

Participants needed: 160
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Eikon TherapeuticsUpdated: Apr 8, 2026Locations: 10
Eligibility criteria

is ≥ 18 years of age at the time of signing the informed consent. [+6]

has not recovered (i.e., to Grade ≤ 1 or to baseline) from prior anti-cancer the... [+10]

Read more
Status: Recruiting

Zimberelimab Anti-PD1 +/- Domvanalimab in Resectable Mmrd Gastric Cancer

A phase II study of peri-operative anti-PD1 (Zimberelimab) +/- anti-TIGIT (Domvanalimab) in resectable mismatch repair deficient (MMRd)/ high micro-satellite instability (MSI-H) gastric/gastro-oesophageal junctional (GOJ) adenocarcinoma (AC)

Participants needed: 50
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Royal Marsden NHS Foundation TrustUpdated: Aug 21, 2025Locations: 9
Eligibility criteria

Age: ≥18 years [+13]

Known severe hypersensitivity reactions to monoclonal antibodies (Grade ≥ 3CTCAE... [+35]

Read more