Mucogingival Deformity - Insufficient Keratinized Tissue

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Review clinical trials related to Mucogingival Deformity - Insufficient Keratinized Tissue. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Modified Coronally Advanced Tunnel for Mandibular Lingual Root Coverage

This study will follow adults who have gum recession on the tongue side of the lower teeth. Participants will receive a gum surgery called the Modified Coronally Advanced Tunnel technique with a connective tissue graft taken from the roof of the mouth. The study will include 20 participants and will follow them for up to 24 months after surgery. The main outcome is how much of the exposed root is covered 6 months after surgery. The study will also measure gum thickness, gum width, tooth sensitivity, healing, patient comfort, satisfaction, and three-dimensional soft tissue changes using intraoral scans.

Participants needed: 20
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: University of PittsburghUpdated: Jun 4, 2026Locations: 1
Eligibility criteria

Age 18-65 years [+7]

Positive urine pregnancy test or self-reported lactation [+8]

Status: Recruiting

Star Matrix vs Autogenous Graft for Gingival Augmentation: Split-Mouth RCT

This split-mouth randomized controlled clinical trial will test whether a ready-to-use collagen membrane (Star Matrix) can widen the protective band of gum tissue (keratinized gingiva) as effectively as the standard free gingival graft harvested from the palate. Central question Can Star Matrix provide the same or better gain in keratinized tissue width-with less patient discomfort and chair-time-than an autogenous graft? Primary objectives Compare the 6-month increase in keratinized tissue width between Star Matrix and autogenous graft sites. Assess patient-reported pain and morbidity associated with each treatment. Secondary objectives Measure operative time, early healing scores, esthetic outcomes, and (optional) histologic quality of the regenerated tissue. Methods Twelve adults with ≤ 2 mm keratinized tissue on contralateral lower-jaw teeth will be enrolled. Each participant receives Star Matrix on one side and a conventional free gingival graft on the other. Follow-up visits at 2, 4, 8, 12 and 24 weeks include clinical measurements, standardized photographs, and a 7-day postoperative pain diary. An optional 2 mm punch biopsy at 6 months is analyzed microscopically.

Participants needed: 12
Trial details
Age: 20-80Biological sex: AllType: InterventionalSponsor: Harvard Medical School (HMS and HSDM)Updated: Feb 27, 2026Locations: 1
Eligibility criteria

Adults 20 - 80 years old who need gingival augmentation on both sides of the low... [+3]

Does not meet any of the inclusion points or is unlikely to follow the schedule [+12]