Muscle Tension Dysphonia

6

Review clinical trials related to Muscle Tension Dysphonia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Voice Therapy Per the Rehabilitation Treatment Specification System

The goal of this study is to evaluate if using evidence-based, standard ingredient and target codes from the Rehabilitation Treatment Specification System - Voice Therapy (RTSS-Voice) in standard of care voice therapy documentation can improve outcomes for patients with muscle tension dysphonia (MTD). The main question it aims to answer is: Since the RTSS-Voice will help clinicians think about their treatment more specifically and in relation to nine evidence-based therapies, will its adoption be associated with improved outcomes? Clinicians across five voice centers will be asked to use the RTSS-Voice to document their voice therapy sessions for patients with MTD. Researchers will compare changes in outcomes between two groups of patients: those treated during the clinician's first year using the RTSS-Voice versus those treated during the clinician's second year using the RTSS-Voice.

Participants needed: 600
Trial details
Age: 14+Biological sex: AllType: InterventionalSponsor: Massachusetts General HospitalUpdated: May 26, 2026Locations: 5
Eligibility criteria

Diagnosis of primary Muscle Tension Dysphonia (pMTD) [+1]

Patients diagnosed with pMTD will be excluded if they have secondary diagnoses r... [+1]

Status: Recruiting

Imaging Genetics of Laryngeal Dystonia

The contribution of genetic risk factors to the development of focal dystonias is evident. However, understanding of how variations in the causative gene expression lead to variations in brain abnormalities in different phenotypes of dystonia (e.g., familial, sporadic) remains limited. The research program of the investigators is set to determine the relationship between brain changes and genetic risk factors in laryngeal dystonia (or spasmodic dysphonia). The researchers use a novel approach of combined imaging genetics, next-generation DNA sequencing, and clinical-behavioral testing. The use of a cross-disciplinary approach as a tool for the discovery of the mediating neural mechanisms that bridge the gap from DNA sequence to the pathophysiology of dystonia holds a promise for the understanding of the mechanistic aspects of brain function affected by risk gene variants, which can be used reliably for the discovery of associated genes and neural integrity markers for this disorder. The expected outcome of this study may lead to better clinical management of this disorder, including its improved detection, accurate diagnosis, and assessment of the risk of developing dystonia in family members.

Participants needed: 410
Trial details
Biological sex: AllType: ObservationalSponsor: Kristina SimonyanUpdated: Dec 2, 2025Locations: 1
Eligibility criteria

Males and females of diverse racial and ethnic background, with age across the l... [+14]

Subjects who are incapable of giving informed consent. [+6]

Status: Recruiting

Translaryngeal Vibration for Hyperfunctional Voice Disorders

Contemporary treatments for hyperfunctional voice disorders such as muscle tension dysphonia (MTD) are effective but typically do not restore voice handicap or voice function to normal thresholds. Recent reports of vibration as a voice therapy modality have been published, but many questions remain about the efficacy of this tool. The current project addresses these problems through a blinded and randomized controlled trial to investigate the efficacy of local translaryngeal vibration for MTD and the dose-response relationship of this modality when compared to treatment without vibration.

Participants needed: 30
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Texas Christian UniversityUpdated: Aug 28, 2025Locations: 1
Eligibility criteria

a) diagnosis by an otolaryngologist of hyperfunctional dysphonia (MTD) without b...

Unable to receive vibration to neck area

Status: Recruiting

Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction

Vocal hyperfunction (VH) is the most commonly treated class of voice disorders by speech-language pathologists and voice therapy is the primary curative treatment. Patients and clinicians report that generalizing improved voicing into daily life is the most significant barrier to successful therapy. We will test if extending biofeedback into the patient's daily life using ambulatory voice monitoring will significantly improve generalization during therapy and if individual patient factors, like how easily they can modify their voice and engagement during therapy, moderate the effects of the biofeedback.

Participants needed: 100
Trial details
Phase: Early Phase 1Age: 18-65Biological sex: AllType: InterventionalSponsor: Massachusetts General HospitalUpdated: May 11, 2025Locations: 2
Eligibility criteria

Diagnosis of vocal fold nodules and polyps. [+2]

Any secondary diagnosis not directly related to phonotrauma, like cyst, sulk, ca... [+3]

Status: Recruiting

RCT Face-to-face Group Voice Therapy vs Telepractice Group Voice Therapy for Muscle Tension Dysphonia

The goal of this clinical trial is to compare face-to-face group voice therapy to telepractice group voice therapy for muscle tension dysphonia (MTD). The main questions it aims to answer are: * The effectiveness of telepractice voice therapy for MTD using a randomized controlled trial study design. * The effectiveness of telepractice group voice therapy using a randomized controlled trial study design. Participants will receive telepractice group voice therapy or face-to-face group voice therapy. Researchers will compare telepractice group voice therapy to face-to-face group voice therapy for patients with MTD to see if it has the same effectiveness.

Participants needed: 168
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Chinese University of Hong KongUpdated: Jul 29, 2024Locations: 1
Eligibility criteria

Above or equal to 18 years of age; [+2]

Dysphonia of neurogenic or psychogenic origin; [+4]

Status: Recruiting

Autonomic Dysfunction in Functional Dysphonia

The first objective of this research project is to compare the occurrence and frequency of symptoms and/or disorders related to autonomic dysfunction in patients with functional dysphonia with gender- and age-matched vocally healthy controls, using a case-control study. The second objective is to compare the effects of a novel therapy based on autonomic nervous system regulation (i.e., ANS therapy: heart rate variability biofeedback), for functional dysphonia versus coventional voice therapy (CVT) alone or in combination with ANS regulation therapy (i.e., ANS therapy + CVT), using a longitudinal randomized controlled trial (RCT).

Participants needed: 100
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: University GhentUpdated: Oct 25, 2023Locations: 1
Eligibility criteria

Not listed