Myasthenia Gravis Associated With Thymoma

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Review clinical trials related to Myasthenia Gravis Associated With Thymoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Thymic Disease, Autoimmunity, and Neuromuscular Junction Integrity in Myasthenia Gravis

The goal of this observational study is to investigate the clinical, immunological, and neuromuscular features associated with the development and progression of myasthenia gravis (MG) in adult patients with thymic abnormalities and/or MG-related antibodies, including individuals with or without clinically manifest disease. The main questions it aims to answer are: * Whether integrated clinical, serological, and histopathological profiles are associated with the presence of MG and can predict disease onset or progression * Wheter systemic immune markers are associated with disease activity, progression, and neuromuscular junction alterations Participants will: * Undergo clinical, neurological, and neurophysiological assessments at baseline and during follow-up * Provide blood samples for serological and immunological analyses * Provide thymic tissue and residual intercostal muscle samples (when undergoing clinically indicated thymectomy) for research analyses * Attend follow-up visits at 6, 12, and 18 months * Record daily symptoms using an electronic patient-reported outcome tool (for participants with MG)

Participants needed: 40
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: IRCCS San RaffaeleUpdated: May 6, 2026Locations: 1
Eligibility criteria

Age ≥18 years at the time of informed consent [+16]

Inability to provide informed consent [+4]

Status: Not yet recruiting

EFG vs IVIG in TAMG

This study is a prospective, multi-center, randomized controlled study to evaluate the efficacy and safety of efgartigimod (EFG) and intravenous immunoglobulin (IVIG) in the perioperative application for acetylcholine receptor (AChR) antibody-positive thymoma patients with myasthenia gravis in order to provide reliable evidence for clinical decision-making.

Participants needed: 64
Trial details
Phase: Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Shanghai Zhongshan HospitalUpdated: Nov 17, 2025Locations: 1
Eligibility criteria

Patients aged >18 years and ≤75 years, with an expected survival time >12 months... [+7]

MGFA type V; [+15]

Status: Recruiting

Myasthenia Gravis Foundation of America Global MG Patient Registry

The goal of this observational study is to learn about the experiences of people living with Myasthenia Gravis (MG) in the United States. The main questions it aims to answer are: * How and when are people with MG diagnosed? * What are the most common symptoms associated with MG? * What treatments are being used to treat MG? * What are the impacts of MG on activities of daily living, employment and quality of life? * What are the experiences with exacerbation, hospitalization and healthcare access for people with MG? Participants will answer a survey to enroll in the study, and be invited to fill out an update survey twice a year.

Participants needed: 3,800
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Myasthenia Gravis Foundation of AmericaUpdated: Sep 27, 2024Locations: 1Duration: 15 Years
Eligibility criteria

age over 18 [+1]

age under 18 [+1]