Status: Recruiting
Lenalidomide in Combination With R-DA-EPOCH in Patients With Untreated DLBCL With MYC Rearrangement
The prognosis of DLBCL with MYC rearrangement is dismal. Previous study showed that lenalidomide in combination with R-CHOP showed promising therapeutic activity and that R-DA EPOCH was superior compared to R-CHOP regimen in this cohort of patients. The investigators therefore design this phase I/II study to investigate the safety and efficacy of lenalidomide in combination with R-DA EPOCH in patients with untreated MYC-rearranged DLBCL.
Participants needed: 81
Trial details
Phase: Phase 1, Phase 2Age: 18-60Biological sex: AllType: InterventionalSponsor: The First Affiliated Hospital with Nanjing Medical UniversityUpdated: Jun 16, 2020Locations: 1
Eligibility criteria
Histologically confirmed DLBCL with MYC rearrangement according to WHO 2016 crit... [+5]
Women who are pregnant or lactating. Patients have breeding intent in 12 months... [+16]