Myofascial Pain

5

Review clinical trials related to Myofascial Pain. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Magnetic Resonance Elastography to Monitor Response to Manual Therapy in Myofascial Pain

The purpose of this research is to develop and test new Magnetic Resonance Imaging (MRI) methods that look at how muscles and tissues under the skin (myofascial tissues) move and respond to pressure. The investigators want to see how these tissues differ between healthy people and people with pain or injury, and how they change after hands-on treatment (Tuina therapy). The results will also be compared to a group that receives standard care without Tuina therapy. The main questions this study aims to answer are: 1. Can MR elastography (MRE) show changes in how the fascia and the layers between muscles move and stretch before and after manual therapy? 2. Do changes seen on MRE scans match changes in pain, function, and other symptoms reported by participants? 3. Can MRE measurements before treatment help predict which participants are most likely to improve with manual therapy? In this randomized controlled trial, participants with myofascial pain will be randomly assigned (randomized) to either the Tuina group or the Usual Care group following a home-based care program without manual therapy. All treatments are noninvasive, hands-on techniques commonly used in clinical practice to reduce tissue tightness and improve movement. Participants will be asked to undergo three MRI scans and to complete questionnaires and other standard clinical assessments about their pain, physical function, and quality of life.

Participants needed: 78
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Mayo ClinicUpdated: Feb 3, 2026Locations: 2
Eligibility criteria

Adult males or females (age ≥ 18 years) [+5]

Pregnancy or breastfeeding [+7]

Status: Recruiting

Multi-modal Imaging of Myofascial Pain - Phase 2

The goal of this study is to evaluate imaging biomarkers for quantitative assessments of myofascial pain and determine their ability to monitor treatment response and predict clinical outcomes.

Participants needed: 100
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Washington University School of MedicineUpdated: Jan 7, 2026Locations: 1
Eligibility criteria

Adults between the ages of 18 and 80 years old. [+5]

Age <18 or >80 years old. [+11]

Status: Not yet recruiting

Effects of Core Strengthening Exercises for Treating TMD

Temporomandibular disorders (TMD) are commonly managed with non-invasive interventions such as manual therapy, therapeutic exercise, relaxation techniques, and patient education. Core strengthening (also known as abdominal strengthening) is a fundamental element of physical therapy that engages deep and superficial trunk musculature to enhance postural control and functional performance. Protocols such as the Shirley Sahrmann progression have demonstrated increased activation of key core stabilizing muscles. Emerging evidence suggests a potential relationship between core stability training and reductions in TMD-related pain, though improvements in functional outcomes remain inconclusive. Biomechanical links between the pelvic floor, spine, and temporomandibular joint further support the rationale for core-focused interventions. Nevertheless, few studies have isolated the effects of core strengthening on TMD symptomatology. This study seeks to determine whether the integration of core stability exercises into TMD management can reduce pain, improve function, and enhance quality of life.

Participants needed: 50
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Loyola UniversityUpdated: Nov 10, 2025Locations: 1
Eligibility criteria

Not listed

Status: Not yet recruiting

The Effects of Ultrasound-guided PRF Versus DN in Myofascial Pain Patients

This study aims to compare the effects of pulsed radiofrequency and drying needling and explore the short-term effect of pulsed radiofrequency in treating myofascial pain patients.

Participants needed: 68
Trial details
Age: 18-70Biological sex: AllType: InterventionalSponsor: Peking Union Medical College HospitalUpdated: Mar 7, 2025
Eligibility criteria

Age 18-70 years old, gender unlimited. [+3]

History of surgery, trauma, or infection in the pain area. [+3]

Status: Not yet recruiting

Effectiveness of Telerehabilitation in Individuals With Temporomandibular Joint Dysfunction and Myofascial Pain

Telerehabilitation is a treatment method that allows the patient to access treatment remotely, regardless of where they are, thanks to developing technology. Telerehabilitation provides us with opportunities such as patient evaluation, monitoring, therapy, consultation, education and patient follow-up. Within the scope of our study, the effects of applying an exercise program to patients through a home exercise program and telerehabilitation will be investigated. The purpose of this study for individuals with temporomandibular joint dysfunction is; To investigate the effectiveness of exercises for myofascial pain through telerehabilitation in individuals with myofascial pain and TMJ dysfunction.

Participants needed: 40
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Biruni UniversityUpdated: Jul 30, 2024Locations: 1
Eligibility criteria

People between the ages of 18-65 with myofascial temporomandibular pain [+4]

Anterior disc displacement without reduction, [+5]