Health Trials

Narcolepsy Type 1 (NT1)

2

Review clinical trials related to Narcolepsy Type 1 (NT1). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase 1, First-in-human Study of VX-433

The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of VX-433 following single and multiple ascending doses, as well as to assess the effect of VX-433 on the PK of midazolam, bupropion, and hydroxybupropion.

Participants needed: 118
Trial details
Phase: Phase 1Age: 18-55Biological sex: AllType: InterventionalSponsor: Vertex Pharmaceuticals IncorporatedUpdated: Jun 8, 2026Locations: 1
Eligibility criteria

Body mass index (BMI) of 18.0 to 30.0 kilogram per meter square (kg/m2), inclusi... [+2]

History of febrile illness or other acute illness that has not fully resolved wi... [+2]

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Status: Recruiting

A Trial of TAK-861 for the Treatment of Narcolepsy With Cataplexy

The main aim of this study is to assess how effective TAK-861 is for treating narcolepsy type 1 and if this effect is maintained over time. Participants will take TAK-861 for a few months and if they meet certain criteria, they will be randomly assigned (by chance, like flipping a coin) to continue taking TAK-861 or take placebo (fake medicine) for up to 4 weeks to see if their narcolepsy symptoms return.

Participants needed: 88
Trial details
Phase: Phase 3Age: 16-70Biological sex: AllType: InterventionalSponsor: TakedaUpdated: May 8, 2026Locations: 18
Eligibility criteria

The participant has a body mass index (BMI) within the range 18 to 40 kilograms... [+2]

The participant has a current medical disorder, other than narcolepsy with catap... [+6]

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