Non-vestibular Schwannoma

1

Review clinical trials related to Non-vestibular Schwannoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with NF2-related schwannomatosis (NF2-SWN, formerly known as neurofibromatosis type 2) with associated progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas. This Master Study is being conducted as a "basket" study that may allow people with multiple tumor types associated with NF2-SWN to receive new drugs throughout this study. Embedded within the Master Study are individual drug substudies. * Investigational Drug Sub-study A: Brigatinib * Investigational Drug Sub-study B: Neratinib * Investigational Drug Sub-study C: Retifanlimab plus bevacizumab

Participants needed: 109
Trial details
Phase: Phase 2Age: 12+Biological sex: AllType: InterventionalSponsor: Scott R. Plotkin, MD, PhDUpdated: May 6, 2026Locations: 6
Eligibility criteria

Bilateral vestibular schwannomas, OR [+11]

Participants who have had chemotherapy within a minimum of 4 weeks prior to Mast... [+102]