NSCLC, Stage I

5

Review clinical trials related to NSCLC, Stage I. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Adjuvant Pembrolizumab vs Observation Following Curative Resection for Stage I Non-small Cell Lung Cancer (NSCLC) With Primary Tumors Between 1-4 cm

A randomized trial of adjuvant Pembrolizumab following surgical resection versus observation following surgical resection in patients with stage I non-small cell lung cancer (NSCLC) with primary tumors between 1-4 cm. Patients will be randomized (1:1) 4-12 weeks following surgery to either: * Arm A: Pembrolizumab 400 mg every 6 weeks × 9 cycles * Arm B: Observation Stratification factors will include: PD-L1 TPS (\<50% vs. ≥50%), and tumor size (1-2 cm vs. \>2-4 cm)

Participants needed: 244
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Greg Durm, MDUpdated: May 5, 2026Locations: 13
Eligibility criteria

The participant (or legally acceptable representative if applicable) must provid... [+27]

Current lung cancer is <1 cm or > 4 cm in size or is stage II, III, or IV. [+18]

Status: Recruiting

A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease

The purpose of this study to find out whether giving BIO 300 in combination with thoracic radiation therapy is effective in preventing pneumonitis in people with non-small cell lung cancer (NSCLC) and interstitial lung disease (ILD).

Participants needed: 25
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Memorial Sloan Kettering Cancer CenterUpdated: Mar 3, 2026Locations: 7
Eligibility criteria

Capable of giving signed informed consent which includes compliance with the req... [+9]

Previous thoracic radiation [+12]

Status: Recruiting

A Study to Describe the Diagnostic and Therapeutic Path of Patients with NSCLC in Early Stage and Locally Advanced

This is a non-interventional, retrospective observational study to improve knowledge regarding the diagnosis and treatments of patients who have/had non-small cell lung cancer (NSCLC), either early stage (stage I-II).

Participants needed: 600
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: MSD Italia S.r.l.Updated: Jan 14, 2025Locations: 25
Eligibility criteria

Patients with stage I-III NSCLC who have received curative surgery or radiothera... [+2]

Patients without availability of medical charts or information required [+1]

Status: Recruiting

Pulmonary Watershed Topographic Map Navigation for Lung Nodule Resection

A method of ICG counterstaining localization under target artery occlusion without cutting,It's a new method of localization of small pulmonary nodules.

Participants needed: 3,000
Trial details
Biological sex: AllType: InterventionalSponsor: Guangdong Provincial People's HospitalUpdated: May 8, 2024Locations: 1
Eligibility criteria

<1cm CTR≤0.75; <1.5cm CTR≤0.5; <2cm CTR≤0.25 Lung nodules [+3]

No surgical video, no postoperative gross specimen and related distance measurem... [+5]

Status: Recruiting

Osimertinib Therapy After Resection in High-risk Stage I EGFRm NSCLC (OSTAR)

This is a prospective, open, single-center, single-arm phase II clinical study with common EGFR-sensitive mutations (Ex19del and L858R) identified in the central laboratory.To evaluate the efficacy and safety of adjuvant Osimertinib therapy in completely resected stage I non-squamous non-small cell lung cancer (NSCLC) with high-risk factors (solid and/or micropapillary component ≥10%, and/or airway spread).

Participants needed: 65
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Tianjin Medical University Cancer Institute and HospitalUpdated: Jan 17, 2023Locations: 1
Eligibility criteria

The subject will voluntarily sign the informed consent in person, and provide th... [+13]

Exposure to other antitumor therapies before enrollment; [+14]