Orthopedic Procedures

4

Review clinical trials related to Orthopedic Procedures. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Comparison of Low-Dose Versus Standard-Dose Hyperbaric Bupivacaine in Spinal Anesthesia

The goal of this randomized controlled trial is to determine whether low-dose hyperbaric bupivacaine provides better hemodynamic stability and postoperative recovery compared with standard-dose hyperbaric bupivacaine in elderly patients undergoing lower limb orthopedic surgery under spinal anesthesia. The main questions it aims to answer are: * Does low-dose hyperbaric bupivacaine reduce the incidence of intraoperative hypotension and bradycardia compared with standard-dose hyperbaric bupivacaine? * Does low-dose hyperbaric bupivacaine improve postoperative recovery profile compared with standard-dose hyperbaric bupivacaine? Researchers will compare elderly patients receiving low-dose hyperbaric bupivacaine with those receiving standard-dose hyperbaric bupivacaine to determine whether a lower intrathecal dose improves cardiovascular stability and recovery without compromising the effectiveness of spinal anesthesia. Participants will: * Provide written informed consent before enrollment. * Undergo elective lower limb orthopedic surgery under spinal anesthesia. * Be randomly assigned to receive either low-dose or standard-dose hyperbaric bupivacaine. * Have their blood pressure, heart rate, and other vital signs monitored throughout the surgical procedure. * Be assessed for intraoperative hypotension and bradycardia according to predefined study criteria. * Be evaluated for postoperative recovery parameters, including motor recovery and readiness for postoperative recovery and mobilization. The information obtained from this study may help identify a safer and more effective spinal anesthetic technique for elderly patients undergoing orthopedic surgery.

Participants needed: 180
Trial details
Phase: Phase 4Age: 65+Biological sex: AllType: InterventionalSponsor: Mayo Hospital LahoreUpdated: Jul 13, 2026Locations: 1
Eligibility criteria

Male or female patients aged 65 years and above. [+3]

Refusal to participate in the study. [+10]

Status: Recruiting

Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery

This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia. We want to find out which medication provides better sedation during the procedure and which one affects early recovery of brain function after surgery. Older adults (65 years and above) undergoing surgery for bone injuries or conditions will participate. We will monitor their sedation levels, blood pressure, heart rate, side effects, and how quickly they recover after surgery. We also want to see if either medication causes fewer problems with thinking and memory shortly after surgery. The study is designed so neither the patients nor the medical staff know which medication is being given, to ensure unbiased results. Participants will be randomly assigned to receive either Remimazolam or Midazolam. The information gathered will help doctors choose the safest and most effective sedative for older patients undergoing orthopedic surgeries, potentially improving patient comfort and recovery.

Participants needed: 120
Trial details
Phase: Phase 3Age: 65+Biological sex: AllType: InterventionalSponsor: Romanian Society for Enteral and Parenteral NutritionUpdated: Oct 1, 2025Locations: 1
Eligibility criteria

Adults aged 65 years or older. [+2]

Patient refusal to participate. [+4]

Status: Recruiting

Physiotherapy vs Telerehabilitation After Volar Plating of Distal Radius Fracture

Trial purpose is to research the outcome comparing traditional physiotherapy vs telerehabilitation after volar plating of distal radius fracture. Patients with distal radius fracture that meet the operative criteria set by the Finnish Current Care guidelines are randomized (1:1 computer generated sequence with random block size) to two parallel groups and will undergo operative treatment and traditional physiotherapy vs telerehabilitation. Baseline data is collected preoperatively and patients are followed at 1, 3 and 12 months after enrollment. The primary end-point is 3 months and the primary outcome is the Patient-Rated Wrist Evaluation (PRWE).

Participants needed: 84
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Töölö HospitalUpdated: Oct 31, 2024Locations: 1
Eligibility criteria

Distal radius fracture, which applies the surgical requirements [+5]

High energy or multiple injuries [+11]

Status: Not yet recruiting

Post Surgical Multimodal Analgesia With Oral Strong Opioids

This is a prospective observational case study, focusing on the clinical effectiveness of oral strong opioids for pain management following common orthopedic surgeries.The study aims to evaluate the effectiveness of multimodal analgesia with oral strong opioids, reduce common opioid-related side effects, and improve patient compliance and satisfaction.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Tri-Service General HospitalUpdated: Aug 15, 2024Locations: 1
Eligibility criteria

Aged 18 or older

Patients who have not received any or have only received oral potent opioids for... [+5]