Osteogenesis Imperfecta Type III

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Review clinical trials related to Osteogenesis Imperfecta Type III. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI)

This is a Phase 1/2 study to determine the safety and efficacy of allogeneic (third party), bone-marrow derived mesenchymal stromal cells (MSCs) for the treatment of Osteogenesis Imperfecta (OI) Type 3. It will evaluate this by looking at whether there are treatment related infusion reactions, and assessing linear growth rates and bone health, both of which are impaired in patients ages 3-10 with Osteogenesis Imperfecta Type 3. This is a single-site non-randomized clinical trial, that will take place at Children's Healthcare of Atlanta (CHOA) at Egleston and Emory Children's Center.

Participants needed: 12
Trial details
Phase: Phase 1, Phase 2Age: 3-10Biological sex: AllType: InterventionalSponsor: Emory UniversityUpdated: May 8, 2026
Eligibility criteria

1. Parent/legal guardian must be willing to sign consent forms to participate in... [+4]

Lacking confirmation of mutation in either COLA1A1 or COL1A2 genes [+5]