Osteonecrosis

7

Review clinical trials related to Osteonecrosis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Effect of HBOT on Femoral Head Avascular Necrosis (AVN)

The primary objective of this study is to determine whether the Hyperbaric Oxygen Therapy (HBOT) conducted under the Marx Protocol improves pain outcomes when combined with core decompression with autologous bone marrow aspirate concentrate to treat patients with femoral head avascular necrosis.

Participants needed: 400
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Yale UniversityUpdated: Jul 1, 2026Locations: 1
Eligibility criteria

Provision of signed and dated informed consent form [+5]

Hip has already collapsed due to severe avascular necrosis (ARCO III or ARCO IV) [+5]

Status: Not yet recruiting

Outcomes From Hyperbaric Oxygen (HBO2) Treatment for Emerging Indications

This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric Oxygen Treatment. The study team aims to collect ongoing data on how well HBOT treats these emerging indications, and to add these data to the growing HBO Registry. The research team hypothesizes that HBOT will result in improvements of the condition of the various emerging indications.

Participants needed: 100
Trial details
Phase: Phase 4Biological sex: AllType: InterventionalSponsor: Jay C. Buckey Jr.Updated: May 5, 2026
Eligibility criteria

Patients referred for HBOT with an emerging indication

Contraindication to hyperbaric oxygen treatment (untreated seizures, pneumothora... [+1]

Status: Recruiting

Alendronate for Osteonecrosis in Adults With Sickle Cell Disease

A prospective, single-arm, intervention study of oral alendronate in adults with sickle cell disease and osteonecrosis

Participants needed: 30
Trial details
Phase: Phase 2Age: 18-80Biological sex: AllType: InterventionalSponsor: University of California, DavisUpdated: Apr 13, 2026Locations: 1
Eligibility criteria

Age 18-80 years with SCD (any genotype, confirmed by hemoglobin electrophoresis... [+3]

Pregnant women [+4]

Status: Recruiting

Early Feasibility Study of Cartilage Defect Repair

Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed conservative care, and is a candidate for surgical intervention to treat.

Participants needed: 15
Trial details
Age: 14-64Biological sex: AllType: InterventionalSponsor: Cytex Therapeutics, Inc.Updated: Feb 17, 2026Locations: 1
Eligibility criteria

At least 14 years of age to no older than 64 years of age Subjects 14-21 years o... [+9]

Current users of nicotine in any form (e.g., cigarettes, e- cigarettes/vaping, c... [+21]

Status: Recruiting

Exactech Shoulder Post Market Clinical Follow-up Study

The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.

Participants needed: 20,000
Trial details
Age: 21+Biological sex: AllType: ObservationalSponsor: ExactechUpdated: Dec 15, 2025Locations: 38
Eligibility criteria

Patient is indicated for shoulder arthroplasty (or has previously undergone shou... [+4]

Osteomyelitis of the proximal humerus or scapula; if a systemic infection or a s... [+17]

Status: Recruiting

PROMIS Evaluation Study

A total of 250 total hip arthroplasties (THA) are performed at the Bezirkskrankenhaus St. Johann. In a majority of those, implants from the company Falcon Medical (Austria) are used. Those implants are undergoing constant development and improvement. To guarantee their clinical performance, this clinical study is evaluating safety and efficacy of all implants produced by Falcon Medical. The purpose of this study is to evaluate the effcacy and safety of implants produced and distributed by Falcon Medical. All patients with primary THA and usage of a Falcon Medical implant are included. The outcome measures include intra-operative complications, early post-operative complications, revision for any cause and patient reported outcome (WOMAC questionnaire). All data is prospectively collected in a standardized fashion.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Bezirkskrankenhaus St. Johann in TirolUpdated: Feb 21, 2023Locations: 1Duration: 20 Years
Eligibility criteria

Primary total hip arthroplasty with the PROMIS stem

n/a

Status: Recruiting

Prospective Registry of Prosthodontic Rehabilitation in Oncology Patients Undergoing Jaw Reconstruction

The investigators aim to develop a prospective database in which patient demographics, surgical, dental, prosthetic and QOL parameters collected during consecutive visits within the framework of routine practice, are being registered for each oncological patient eligible for (immediate/delayed) fixed prosthodontic rehabilitation at time of oral cavity reconstruction

Participants needed: 55
Trial details
Biological sex: AllType: ObservationalSponsor: AZ Sint-Jan AVUpdated: Feb 28, 2022Locations: 1Duration: 5 Years
Eligibility criteria

Patients of all ages [+4]

Patients with a clinically confirmed diagnosis of osteonecrosis not related to a... [+2]