Health Trials

OTOF Gene Mutation

2

Review clinical trials related to OTOF Gene Mutation. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes

The purpose of this study is to follow the natural history of non-syndromic hearing loss caused by mutations in two genes (GJB2 or OTOF) in children up to 16 years of age.

Participants needed: 180
Trial details
Age: Up to 16Biological sex: AllType: ObservationalSponsor: SensorionUpdated: Jun 1, 2026Locations: 1
Eligibility criteria

Aged ≤ 16 years on the date of signed informed consent for cohort 1 and ≤ 10 yea... [+4]

Other type of deafness, such as unilateral deafness, persistent conductive deafn... [+2]

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Status: Recruiting

A Phase I/II Clinical Trial with SENS-501 in Children Suffering from Severe to Profound Hearing Loss Due to Otoferlin (OTOF) Mutations

This study intends to assess safety, tolerability, and efficacy of SENS-501 in children between the ages of 6-31 months with pre-lingual hearing loss due to a mutation in the Otoferlin gene.

Participants needed: 12
Trial details
Phase: Phase 1, Phase 2Age: 6-31Biological sex: AllType: InterventionalSponsor: SensorionUpdated: Sep 26, 2024Locations: 2
Eligibility criteria

Children (male or female) ≥ 6 to ≤ 31 months at the time of inclusion [+5]

History of chronic, acute, or major disease, or unspecified reasons, that in the... [+6]

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