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Patients With Central Nervous System Relapse Who Did Not Receive Cranial Radiation or Bone Marrow Transplantation

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Condition / disease
Location
Status: Recruiting

Orphan Indications for CD19 Redirected Autologous T Cells

This is an open-label, four-cohort, phase 2 study to determine the efficacy of CART19 in pediatric and young adult patientswith hypodiploid (Cohort A) or t(17;19) B-ALL (Cohort B), infants with very high risk KMT2A B-ALL (Cohort C), and in patients with central nervous system (CNS) relapse who did not receive cranial radiation (XRT) or bone marrow transplantation (BMT) (Cohort D).

Participants needed: 133
Trial details
Phase: Phase 2Age: 0-29Biological sex: AllType: InterventionalSponsor: Stephan Grupp MD PhDUpdated: Mar 6, 2026Locations: 1
Eligibility criteria

Signed informed consent form must be obtained prior to any study procedure. [+5]

For subjects with a CNS relapse, prior cranial XRT or BMT for the current relaps... [+7]

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