PD-L1 Negative

2

Review clinical trials related to PD-L1 Negative. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

This research study involves testing the safety and efficacy of an investigational intervention for patients with triple-negative breast cancer (TNBC) that has spread, or metastasized, to other parts the body and is PD-L1-negative. The names of the study interventions involved in this study are: * Sacituzumab govitecan (Trodelvy™;IMMU-132) * Pembrolizumab (Keytruda®; MK-3475)

Participants needed: 110
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Dana-Farber Cancer InstituteUpdated: Apr 29, 2026Locations: 15
Eligibility criteria

Participants must have histologically or cytologically confirmed invasive breast... [+25]

Has received prior systemic anti-cancer therapy, including investigational agent... [+14]

Status: Recruiting

Neoadjuvant Immunochemotherapy in PD-L1-negative LACC

This is a multicenter, prospective, single-arm, phase 2 clinical trial designed to evaluate the therapeutic efficacy of the NACI (neoadjuvant chemotherapy plus Camrelizumab) for PD-L1-negative locally advanced cervical cancer.

Participants needed: 40
Trial details
Phase: Phase 2Age: 18-70Biological sex: FemaleType: InterventionalSponsor: Tongji HospitalUpdated: Mar 20, 2025Locations: 12
Eligibility criteria

FIGO 2018 stage IB3, IIA2, or IIB/IIIC1r (tumor size>4cm) cervical cancer and wi... [+8]

Active, known, or suspected autoimmune disease, or a history of an autoimmune di... [+20]