Health Trials

Pemetrexed

2

Review clinical trials related to Pemetrexed. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis

This phase I/II study is to evaluate the recommended dose, safety, feasibility, and therapeutic response of intrathecal dual checkpoint inhibitor (targeting PD-1 and CTLA-4 with QL1706) in combination with pemetrexed in patients with leptomeningeal metastasis.

Participants needed: 34
Trial details
Phase: Phase 1, Phase 2Age: 21-75Biological sex: AllType: InterventionalSponsor: Guangzhou Medical UniversityUpdated: May 18, 2025Locations: 2
Eligibility criteria

Histologically or cytologically confirmed diagnosis of solid tumors; Cerebrospin... [+2]

Any evidence of nervous system failure, including severe encephalopathy, grade 3... [+3]

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Status: Recruiting

Neoadjuvant Befotertinib Combined Bevacizumab or Platinum-based Double Chemotherapy for Resectable Locally-advanced EGFR Mutation-positive Non-Small Cell Lung Cancer

This study targeted patients with resectable stage II-IIIA non-small cell lung cancer with EGFR mutation

Participants needed: 60
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Peng ZhangUpdated: Jan 6, 2025Locations: 1
Eligibility criteria

NSCLC patient with EGFR sensitive mutation as confirmed by needle biopsy; [+9]

The patient has undergone any systemic anti-cancer treatment for NSCLC, includin... [+9]

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