Perineal Trauma

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Review clinical trials related to Perineal Trauma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Papaverine for Prevention of Perineal Trauma

Perineal trauma is a common complication of vaginal delivery, particularly among primiparous patients, and may result in short- and long-term maternal morbidity, including pain, dyspareunia, and pelvic floor dysfunction. Papaverine hydrochloride, a smooth muscle relaxant with vasodilatory properties, has been shown to improve tissue relaxation and has been used safely in obstetric settings. This prospective randomized double-blind placebo-controlled study aims to evaluate whether intrapartum intravenous papaverine hydrochloride (80 mg), administered at full cervical dilatation, reduces the rate of perineal trauma among primiparous patients undergoing vaginal delivery. Eligible participants will be randomized in a 1:1 ratio to receive either intravenous papaverine hydrochloride or placebo (normal saline). Maternal, obstetric, and neonatal outcomes, including the rate and severity of perineal trauma, obstetric anal sphincter injuries (OASIS), postpartum hemorrhage, and neonatal outcomes, will be assessed.

Participants needed: 412
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: Dr Raneen Abu ShqaraUpdated: Jun 11, 2026
Eligibility criteria

Primiparous patients aged 18 years or older [+5]

Multiple gestation [+9]

Status: Recruiting

Hands-on vs Hands-off Techniques in Perineal Protection

Perineal tears are frequent during vaginal delivery. This study evaluates the impact of hands-on versus hands-off techniques on perineal and neonatal outcomes to determine the most effective protective strategy.

Participants needed: 737
Trial details
Age: 18+Biological sex: FemaleType: ObservationalSponsor: Azienda ULSS 8 BericaUpdated: Mar 25, 2026Locations: 1
Eligibility criteria

Donne incinte nullipare o multipare [+9]

Status: Not yet recruiting

Maternal Musculoskeletal Factors of the Hip, Lumbopelvic, Abdominal and Pelvic Floor Regions and Their Association With Mode of Delivery and Postpartum Pelvic Floor Dysfunction

This prospective observational cohort study aims to investigate the association between maternal musculoskeletal factors of the hip, lumbopelvic, abdominal, and pelvic floor regions and childbirth outcomes, as well as their consequences on pelvic floor function during the postpartum period. A total of 376 pregnant women will be recruited at 36 weeks of gestation and followed until 12 weeks postpartum. Musculoskeletal assessments will include hip range of motion, lumbopelvic mobility, abdominal muscle function, and pelvic floor strength and morphology. Obstetric outcomes such as mode of delivery and perineal trauma will be recorded after childbirth. The study will analyze whether maternal musculoskeletal function during late pregnancy is associated with delivery mode and pelvic floor dysfunction in the postpartum period.

Participants needed: 376
Trial details
Age: 18-45Biological sex: FemaleType: ObservationalSponsor: Universitat Internacional de CatalunyaUpdated: Mar 17, 2026
Eligibility criteria

Pregnant women aged 18 years or older [+4]

Multiple pregnancy [+4]