Periprosthetic Fracture Around Prosthetic Joint Implant

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Review clinical trials related to Periprosthetic Fracture Around Prosthetic Joint Implant. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Investigating Periprosthetic Fracture Cultures in Arthroplasty

This study aims to improve how doctors diagnose infections in patients with broken bones around joint replacements. Currently, there are no clear guidelines to help determine when an infection is present, making treatment decisions difficult. By studying how often infections are found through lab tests and identifying factors that predict infection, the investigators hope to create better ways to diagnose and care for these patients.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: University of ChicagoUpdated: Dec 22, 2025Locations: 1
Eligibility criteria

Adult patients (>18 years old) with periprosthetic fractures around primary or r... [+2]

Patients undergoing non-operative management for periprosthetic fractures [+2]

Status: Recruiting

Periprosthetic Fracture Registry (PPFx)

This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty. A registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity and mortality, improved patient safety, improved quality of care and medical decision-making, reduced medical spending, and advances in orthopaedic science.

Participants needed: 600
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: AO Innovation Translation CenterUpdated: Sep 12, 2025Locations: 13Duration: 12 Months
Eligibility criteria

Age ≥18 years [+6]

Pregnancy or women planning to conceive within the study period [+1]

Status: Recruiting

Weight-Bearing CT and Conventional Periprosthetic Distal Knee Fractures

Total knee arthroplasty (TKA) is a surgical procedure commonly conducted for patients with end-stage knee osteoarthritis, often leading to improved pain relief and function. However, for patients that have suffered an associated periprosthetic fracture, a broken bone that occurs around the implant of a TKA, they may receive sub-optical care due to a lack of a trustworthy assessments for component fixation and fracture healing in the literature. The prevalence of TKA surgeries is increasing annually and is projected to rise further due to an ageing population and obesity issue. By extension to this primary surgery, more Canadians will require an invasive revision surgery that risks patient morbidity and mortality. Thus, it is imperative to set a standard for fixation and bone healing assessments to lessen revision burdens and improve patient outcomes. CT imaging can effectively visualize areas of incomplete bone ingrowth that may be hidden from overlapping anatomy on plain radiographs, which remains the go-to imaging modality for orthopaedic surgeons to assess periprosthetic fracture healing. The purpose of this prospective cross-sectional study is to examine the efficacy of weight-bearing CT as a diagnostic tool for 20 participants who experienced a distal femur periprosthetic fracture and underwent revision surgery using a fracture fixation plate and screws. Participants will be scanned under loaded and unloaded conditions. Radiographic outcomes will be evaluated, including bone segment displacement and its relation to participants' reports of pain.

Participants needed: 20
Trial details
Age: 50-90Biological sex: AllType: InterventionalSponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sUpdated: Apr 4, 2025Locations: 1
Eligibility criteria

Underwent revision surgery for repair of a distal femur fracture surrounding a p... [+4]

Does not understand English [+3]