Persistent Post-concussive Symptoms

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Review clinical trials related to Persistent Post-concussive Symptoms. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms

Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity. Currently, effective treatments for PPCS are limited, despite their lasting and debilitating impact. Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive neuromodulation technique, holds promise as a therapeutic option by leveraging the bottom-up modulation of brain activity via the auricular branch of the vagus nerve. This study aims to evaluate the neurophysiological and clinical effects of taVNS on brain activity and symptomatology in patients with PPCS through a randomized, controlled, double-blind trial.

Participants needed: 48
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: University of LiegeUpdated: Jun 12, 2025Locations: 1
Eligibility criteria

Age between 18 and 65; [+3]

History of chronic neurological or psychological disorders (still untreated 6 mo... [+4]

Status: Not yet recruiting

SPINEPASS: SPINE Self-management Techniques for Persistent Headache After Concussion: Physical Therapy Targeting Autonomic and Dura Mater Function.

This is a prospective randomized controlled trial comparing two different physical therapy approaches to the treatment of posttraumatic headache with autonomic symptoms. AIM 1: To establish the efficacy of SPINEPASS against Standard Physical Therapy to reduce headache disability and impact amongst patients with persistent post-concussion headache. AIM 2: Demonstrate the superiority of SPINEPASS in the efficient self-management of headache. Demonstrate its appropriateness, acceptability, and feasibility and gain patient insights among patients with PPTH compared to standard PT.

Participants needed: 120
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: The University of QueenslandUpdated: Mar 18, 2025Locations: 1
Eligibility criteria

Persistent Post-traumatic headache (PPTH) duration =or > 4 weeks. [+4]

Contraindications for spinal or graded general exercise. [+7]