Health Trials

Philadelphia-Negative ALL

2

Review clinical trials related to Philadelphia-Negative ALL. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study of 19-28z/IL-18 in People With Acute Lymphoblastic Leukemia (ALL)

Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory to be changed (modified) to become 19-28z/IL-18, the CAR T-cell therapy that participants will receive during the study. Making the participants' study therapy will take about 2-4 weeks.

Participants needed: 18
Trial details
Phase: Phase 1Age: 17+Biological sex: AllType: InterventionalSponsor: Memorial Sloan Kettering Cancer CenterUpdated: Feb 10, 2026Locations: 7
Eligibility criteria

For Philadelphia chromosome (Ph) negative B-ALL: Refractory or relapsed disease... [+14]

Concurrent active malignancy excluding: nonmelanoma skin cancer or localized sol... [+15]

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Status: Recruiting

RDC-Blinatumomab Versus hyperCVAD for Ph-negative B-ALL.

In this study, newly diagnosed non-elderly patients with Philadelphia chromosomal negative (PH-) B-ALL were enrolled and 1:1 randomised into Reduced-intensity chemotherapy followed by Blinatumomab cohort or hyperCVAD cohort as induction therapy. The clinical remission rate, MRD negative rate and treaty-related adverse reactions were evaluated.

Participants needed: 124
Trial details
Phase: Phase 2Age: 15-65Biological sex: AllType: InterventionalSponsor: Chen SuningUpdated: Apr 4, 2024Locations: 1
Eligibility criteria

Age 15-65 [+6]

Ph+ (BCR-ABL1 positive) ALL [+9]

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