Pilonidal Sinus Disease

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Review clinical trials related to Pilonidal Sinus Disease. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Silac Versus Phenol for the Treatment of Pilonidal Sinus Disease: A Randomized Controlled Trial

Pilonidal sinus disease is a common condition affecting young adults and is associated with pain, infection, and reduced quality of life. Various minimally invasive treatment options have been developed to reduce recurrence and improve recovery time. Among these methods, Silac (laser ablation) and phenol application are frequently used techniques. The aim of this prospective randomized controlled trial is to compare the effectiveness and safety of Silac and phenol treatments in patients with primary pilonidal sinus disease. Eligible patients will be randomly assigned to receive either Silac or phenol treatment. The primary outcome of the study is recurrence rate. Secondary outcomes include postoperative pain, healing time, time to return to work, patient satisfaction, and treatment cost. Patient recruitment is planned over a 6-month period, and each participant will be followed for 6 months after treatment. The total study duration will be 12 months. The results of this study are expected to provide evidence to guide the selection of minimally invasive treatment options for primary pilonidal sinus disease.

Participants needed: 200
Trial details
Age: 18-64Biological sex: AllType: InterventionalSponsor: Izmir City HospitalUpdated: Feb 19, 2026Locations: 1
Eligibility criteria

Age between 18 and 64 years [+4]

Recurrent or previously operated pilonidal sinus disease [+6]

Status: Recruiting

The Effect of Local Anesthesia Techniques on Postoperative Pain After Laser Treatment of Pilonidal Sinus

"Assessment of postoperative pain with conventional and tumescent local anesthesia in the laser treatment of pilonidal sinus." The aim of this study is to: examine the possible difference in postoperative pain between two local anesthesia procedures after laser treatment of pilonidal sinus disease on the first and second postoperative day, as well as one week after surgery. During the procedure, two well-established anesthesia techniques are used to make the surgical area painless. The first is local anesthesia, in which the anesthetic is injected into and under the skin. The second procedure is tumescent anesthesia. In this procedure, the anesthetic in diluted form is introduced into the subcutaneous tissue. Both procedures are used in surgery and are standard methods of local anesthesia.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Opća županijska bolnica PožegaUpdated: Feb 13, 2026Locations: 1
Eligibility criteria

Diagnosed pilonidal sinus disease [+2]

Recurrent pilonidal sinus [+2]

Status: Recruiting

Effect of Phenol Addition to Laser Treatment on Epithelialization and Healing Process in Pilonidal Sinus

This study compares two treatment approaches for pilonidal sinus disease: laser treatment alone versus laser treatment combined with phenol application. Pilonidal sinus is a common condition that affects young adults and can cause significant discomfort and time off work. Participants will be randomly assigned to receive either laser treatment only (Group A) or laser treatment plus phenol application (Group B). Both treatments are minimally invasive and performed under local anesthesia as day surgery procedures. The main goal is to determine if adding phenol to laser treatment speeds up the healing process (epithelialization) and improves patient outcomes. We will measure healing time, pain levels, return to daily activities, and quality of life over a 3-month follow-up period. This research may help develop more effective treatment protocols that reduce healing time and improve patient comfort for people with pilonidal sinus disease.

Participants needed: 130
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research HospitalUpdated: Jun 17, 2025Locations: 1
Eligibility criteria

Age 18 years and older [+4]

Age under 18 years [+8]