Status: Recruiting
Role of ACTG2 Variants in Smooth Muscle Determination and Function in Pediatric Intestinal Pseudo-obstruction.
The primary objective of this study is to describe the transcriptional impact of R178, R257, R40 or A136 variants of the ACTG2 gene on iPS differentiation mechanisms up to organoids derived from PIPO patient samples versus those derived from control / WT patients (generation of IPS from cultured cell lines), at different stages of their experimental ex vivo development.
Participants needed: 4
Trial details
Age: 4+Biological sex: AllType: InterventionalSponsor: University Hospital, GrenobleUpdated: May 27, 2026Locations: 3
Eligibility criteria
Minor or adult patient ≥ 4 years of age [+5]
Patients with a history of radiotherapy treatment [+1]