Piriformis Syndrome

12

Review clinical trials related to Piriformis Syndrome. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Comparing Two Soft Tissues Technique on Piriformis Syndrome Patients

Piriformis Syndrome is a neuromuscular condition with symptoms of pain, numbness and tingling tracing the route of the sciatic nerve, due to the nerve impingement by the piriformis muscle. Two common manual therapy techniques used to treat musculoskeletal conditions are myofascial release and post-isometric relaxation. The intent of the research is to evaluate the effects of myofascial release (MFR) as compared to post-isometric relaxation (PIR) in improving pain and lower extremity function in piriformis syndrome (LEFS). The study population involved 32 individuals aged between 20 to 50 years who will be randomly assigned to two groups; a group that received MFR and a group that received PIR. Both groups received the baseline treatment for four weeks. The Visual Analog Scale (VAS) will be employed to gauge the amount of pain, while the LEFS was used to measure functional mobility

Participants needed: 26
Trial details
Age: 20-50Biological sex: AllType: InterventionalSponsor: University of FaisalabadUpdated: Jun 30, 2026Locations: 1
Eligibility criteria

Positive Lasegue sign [+3]

Lower extremity injuries including ligament, tendon injuries, muscle strains as... [+8]

Status: Not yet recruiting

Comparative Effects of Post-Isometric Relaxation and Reciprocal Inhibition Techniques inPiriformis Syndrome

Piriformis Syndrome (PS) is a condition which is characterized by pain, numbness, and limited range of motion (ROM) due to compression or irritation of the sciatic nerve by the piriformis muscle. It often leads to discomfort in the buttock region, radiating pain along the posterior thigh, and functional limitations in daily activities. Manual therapy techniques, particularly Muscle Energy Techniques (METs), have been widely used for the management of musculoskeletal dysfunctions, including piriformis syndrome.

Participants needed: 42
Trial details
Age: 25-40Biological sex: AllType: InterventionalSponsor: Riphah International UniversityUpdated: Jun 12, 2026Locations: 1
Eligibility criteria

Both gender male and female. [+5]

Lumber disc herniation or radiculopathy confirmed by imaging or neurological sig... [+6]

Status: Recruiting

Comparative Effects Of Post Isometric Relaxation Versus Active Isolated Stretch In Patients With Piriformis Syndrome

The purpose of this study is to evaluate the comparative effects of post-isometric relaxation (PIR) and active isolated stretch (AIS) techniques on reducing pain, improving range of motion, and decreasing functional disability in individuals with piriformis syndrome. A total of 40 participants will be recruited, aged 20-55 yrs, with confirmed piriformis syndrome. Participants will be randomized into two equal groups. Group A (post isometric relaxation) and Group B (active isolated stretch). Both groups will receive Conventional Therapy (Thermotherapy, Electrotherapy). Study variables include: * Independent Variable: Post Isometric Relaxation and Active Isolated Stretching. * Dependent Variables: Pain (measured by Visual Analog Scale), Functional Disability (assessed via Oswestry Disability Index), Range of Motion (assessed via Goniometer). * Control Variables: Age, Gender, BMI, Baseline Pain/ Disability Scores/ROM The intervention will last 2 weeks with 6 sessions (3 sessions per week). Assessments will be conducted at baseline (Week 1, Pre-treatment) and Post every second session. Data will be analyzed to compare immediate and short-term effects of the two interventions. This study aims to provide evidence for targeted manual therapy approaches in priformis syndrome, potentially guiding clinicians toward the most effective technique for pain reduction, improve ROM and decrease functional disability.

Participants needed: 40
Trial details
Age: 20-55Biological sex: AllType: InterventionalSponsor: Foundation University IslamabadUpdated: May 20, 2026Locations: 1
Eligibility criteria

Age between 20-55 years [+5]

Malignancies [+6]

Status: Recruiting

Strain-Counterstrain Treatment of Piriformis Pain

The purpose of this investigator-initiated study is to provide an efficient and non-invasive treatment option for pain caused by the piriformis muscle.

Participants needed: 30
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Loma Linda UniversityUpdated: Apr 24, 2026Locations: 1
Eligibility criteria

18 to 65 years of age [+1]

Less than 45 degrees of active hip flexion, less than 5 degrees of active hip in... [+9]

Status: Not yet recruiting

Diagnostic Accuracy of Clinical Tests and Diagnostic Criteria for Piriformis Syndrome

Piriformis syndrome is a clinical condition characterized by buttock pain and/or sciatic-like symptoms, and its diagnosis remains challenging because there is no universally accepted diagnostic standard. This study aims to evaluate the diagnostic accuracy of commonly used diagnostic criteria and clinical tests for piriformis syndrome. Participants with suspected piriformis syndrome will undergo standardized physical examination and assessment of predefined diagnostic criteria. Ultrasound-guided injection of 5 mL of 2% lidocaine into the piriformis muscle will be used as the reference diagnostic procedure. A reduction of 50% or more in pain after injection will be considered confirmation of piriformis syndrome. The diagnostic performance of clinical tests and diagnostic criteria will be analyzed accordingly.

Participants needed: 75
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Istanbul University - CerrahpasaUpdated: Mar 17, 2026Locations: 1
Eligibility criteria

Adults aged 18 to 75 years [+2]

History of injection to the lumbar, hip, or gluteal region within the last 3 mon... [+11]

Status: Not yet recruiting

Ultrasound-Guided Interfascial Hydrodissection for Gluteal Myofascial Pain in Piriformis Syndrome: A Prospective Study

This randomized, double-blind prospective trial investigates whether ultrasound-guided interfascial hydrodissection using 10% dextrose is more effective than dry needling in treating gluteal myofascial pain coexisting with piriformis syndrome. Following diagnostic piriformis injection response, eligible patients will be randomized into two treatment arms and followed at 1 hour, 1 week, 1 month, and 3 months. The primary hypothesis is that interfascial hydrodissection will provide superior long-term analgesic outcomes due to fascial separation, neuromodulation, and nociceptor suppression.

Participants needed: 42
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: Istanbul University - CerrahpasaUpdated: Mar 13, 2026Locations: 1
Eligibility criteria

Adults aged 18 to 75 years [+2]

Active lumbar radiculopathy [+6]

Status: Recruiting

Instrument-Assisted Soft Tissue Mobilization Versus PNF Stretching in Athletes With Piriformis Syndrome

A 12-month randomized controlled trial will be conducted at Pakistan Sports Board, Lahore, with 40 athletes (18-35 years) randomly allocated to IASTM (n=20) or PNF (n=20) groups. Interventions were administered 3 times/week for 4 weeks. Outcomes included Numeric Pain Rating Scale (NPRS), goniometric hip ROM, and Oswestry Disability Index (ODI).

Participants needed: 40
Trial details
Age: 18-35Biological sex: AllType: InterventionalSponsor: Riphah International UniversityUpdated: Jul 29, 2025Locations: 1
Eligibility criteria

Professional Athletes aged 18 to 35 years. [+5]

Trauma history from last 6 months. [+4]

Status: Recruiting

Effects of Facilitated Positional Release Technique ( FPRT) Vs Manual Myofascial Release Technique in Female Patients With Piriformis Syndrome.

This study is a randomized control trial, and the purpose of this study is to determine the "Effects of Facilitated Positional Release Technique ( FPRT) Vs Manual Myofascial Release Technique in Female Patients with Piriformis Syndrome.

Participants needed: 38
Trial details
Age: 25-50Biological sex: FemaleType: InterventionalSponsor: Foundation University IslamabadUpdated: Jul 1, 2025Locations: 1
Eligibility criteria

• 25-50 years Only females Diagnosed piriformis syndrome Pain from 2 months

Lumbar Radiculopathy Fracture trauma to lumbar spine surgery/ total hip replacem...

Status: Recruiting

Chronic Pelvic Pain in Females and Males

Pelvic pain is under-reported in healthy adults. Many patients with pelvic pain under-estimate the problem. Chronic pelvic pain can be managed properly, if diagnosed promptly. This is a quantitative analysis of prospective clinical data. It evaluates the management of pelvic pain in a cohort population, and analyzes the treatment outcome.

Participants needed: 1,000
Trial details
Age: 20-99Biological sex: AllType: ObservationalSponsor: Salem Anaesthesia Pain ClinicUpdated: Jan 27, 2025Locations: 1
Eligibility criteria

Patients with chronic pelvic pain [+4]

Patients with spinal pain [+1]

Status: Recruiting

"Effects of Facilitated Positional Release Technique( FPRT) Vs. Manual Myofascial Release Technique in Female Patients With Piriformis Syndrome

This study is a randomised control trial and the purpose of this study is to determine the "Effects of Facilitated Postional Release Technique( FPRT) Vs Manual Myofascial Release Technique in Female Patients With Piriformis Syndrome.

Participants needed: 38
Trial details
Age: 25-50Biological sex: FemaleType: InterventionalSponsor: Foundation University IslamabadUpdated: Dec 31, 2024Locations: 1
Eligibility criteria

patients with Piriformis syndrome [+4]

Lumbar Radiculopathy [+4]

Status: Recruiting

Effects of Reciprocal Inhibition Versus Post Facilitation Muscle Energy Technique Along With Conventional Physical Therapy in Patients With Piriformis Syndrome: a Randomized Controlled Trial

This study is a randomized controlled trial and the purpose of this study is to compare the effects of reciprocal inhibition versus post facilitation muscle energy technique along with conventional physical therapy in patients with piriformis syndrome in terms of pain, range of motion at hip joint and functional disability.

Participants needed: 44
Trial details
Age: 20-50Biological sex: AllType: InterventionalSponsor: Foundation University IslamabadUpdated: Aug 2, 2024Locations: 1
Eligibility criteria

Age: 20-50 years [+5]

Active infection [+7]

Status: Recruiting

Comparasion of Autogenic Inhibition and Reciprocal Inhibition Muscle Energy Techniques (METS) in Piriformis Syndrome

To compare the effects of Autogenic Inhibition and Reciprocal Inhibition Muscle Energy Techniques (METS) in Piriformis Syndrome

Participants needed: 32
Trial details
Age: 25-45Biological sex: AllType: InterventionalSponsor: Riphah International UniversityUpdated: Jun 14, 2024Locations: 1
Eligibility criteria

Both genders with ages between 25-45 years. [+5]

Hip Degenerative changes. [+5]