Polypoidal Choroidal Vasculopathy (PCV)

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Review clinical trials related to Polypoidal Choroidal Vasculopathy (PCV). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Efficacy and Durability of a Personalized Treat-and-extend Regimen of Faricimab for Treatment-naive Polypoidal Choroidal Vasculopathy

To evaluate the Efficacy of a personalized treat-and-extend regimen of faricimab for treatment-naive polypoidal choroidal vasculopathy

Participants needed: 50
Trial details
Phase: Phase 3Age: 50+Biological sex: AllType: InterventionalSponsor: Yeungnam University College of MedicineUpdated: Mar 10, 2026Locations: 1
Eligibility criteria

Presence of active polypoidal lesions in the macula as shown by Indocyanine gree... [+6]

Previous treatment with any anti-VEGF drugs or faricimab or investigational drug... [+22]

Status: Recruiting

Prospective Trial of the Efficacy and Safety of a Personalized Regimen of High-dose Aflibercept 8mg on Treatment-naive Polypoidal Choroidal Vasculopathy: the PALLAS Trial

The purpose of this study is to evaluate the efficacy and safety of the aflibercept 8 mg used in a personalized regimen, with flexible loading dose and treatment intervals from 8 to 24 weeks in eyes with treatment-naive PCV.

Participants needed: 50
Trial details
Phase: Phase 3Age: 19+Biological sex: AllType: InterventionalSponsor: Yeungnam University College of MedicineUpdated: Feb 5, 2026Locations: 1
Eligibility criteria

Signed informed consent must be obtained prior to participation in the study. [+3]

Ocular conditions/disorders at screening or baseline which could, in the opinion... [+7]

Status: Not yet recruiting

A Prospective, Multicenter, Open-label, Randomized Clinical Trial to Evaluate the Efficacy, Durability, and Safety of Aflibercept 8mg in Different Treatment Regimens in Chinese Patients With Polypoidal Choroidal Vasculopathy (PCV)

The goal of this clinical trial is to investigate the efficacy, durability, and safety of aflibercept 8 mg in treating Polypoidal Choroidal Vasculopathy (PCV) in Chinese naive patients. The main questions it aims to answer are: 1. What is the change in Best Corrected Visual Acuity (BCVA) at Week 52 from baseline in different treatment regimens? 2. What proportion of patients achieve sustained disease control after receiving the loading dose? Participants will: * Receive intravitreal aflibercept 8 mg loading doses (3 initial monthly doses). * In Arm A: * Undergo reinjections based on disease activity, with follow-up examinations every 4 weeks until week 48. * Return for an end-of-study visit at week 52. * In Arm B: * Undergo an examination at week 12 and subsequent treatments based on disease activity, with a maximum interval of 20 weeks and a minimum interval of 8 weeks between doses if the disease remains inactive. * Return for an end-of-study visit at week 52. This study will assess the efficacy, safety and durability of aflibercept 8mg in these 2 regimens.

Participants needed: 174
Trial details
Phase: Phase 4Age: 50+Biological sex: AllType: InterventionalSponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineUpdated: Jan 26, 2026Locations: 20
Eligibility criteria

Patients who fully understand the content, process, and possible AE of the study... [+5]

Treatment with investigational therapy (anti-VEGF, corticosteroid, laser photoco... [+9]