Postoperative Aortic Dissection Follow-up

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Condition / disease
Location
Status: Not yet recruiting

AI-Guided Intensified Follow-up After Surgery for Acute Type A Aortic Dissection

This multicenter, prospective, randomized controlled trial will evaluate whether an artificial intelligence (AI) multimodal prediction model-guided intensified follow-up strategy improves 1-year outcomes after surgery for acute Stanford type A aortic dissection. Eligible adult patients who have undergone open surgical repair or open plus endovascular/hybrid repair and are clinically stable to enter the postoperative follow-up phase will be randomized 1:1 to usual postoperative follow-up or AI-guided intensified follow-up. The AI-guided arm will receive usual follow-up plus an AI-generated risk stratification report for 1-year mortality and adverse aortic remodeling. Higher-risk patients may receive more frequent follow-up, prioritized CTA review, multidisciplinary assessment, and targeted management reminders. The primary outcome is all-cause mortality through postoperative day 365. Key secondary outcomes include aortic reintervention, adverse aortic remodeling, and ICU readmission within 1 year.

Participants needed: 1,314
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Second Affiliated Hospital, School of Medicine, Zhejiang UniversityUpdated: Jun 3, 2026
Eligibility criteria

1. Age 18 years or older. 2. Acute Stanford type A aortic dissection confirmed b...

1. Predominantly chronic type A dissection, traumatic dissection, or iatrogenic...