Postoperative Care

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Review clinical trials related to Postoperative Care. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Effect of Postoperative Holistic Nursing Care on Children's Satisfaction and Nursing Image Perception

This randomized controlled study aims to evaluate the effect of holistic nursing care applied during the postoperative period on children's satisfaction with care and their perception of nursing image. The study will be conducted in the Pediatric Surgery Clinic of Antalya Training and Research Hospital with children aged 8 to 11 years who undergo surgical procedures. Participants will be randomly assigned to either an intervention group or a control group. All children will receive routine postoperative nursing care. In addition to routine care, children in the intervention group will participate in a mandala coloring activity accompanied by music. This supportive activity is designed to help children relax, express their feelings, and improve their hospital experience. Data will be collected using standardized questionnaires that measure children's satisfaction with nursing care and their perception of nurses. The study aims to determine whether holistic nursing practices can improve children's satisfaction and positively influence how they perceive the nursing profession.

Participants needed: 70
Trial details
Age: 8-11Biological sex: AllType: InterventionalSponsor: Akdeniz UniversityUpdated: Jul 13, 2026Locations: 1
Eligibility criteria

Children aged 8 to 11 years [+5]

Cognitive impairment preventing completion of questionnaires [+3]

Status: Not yet recruiting

Risk Factors of Atrial Fibrillation After Cardiac Surgery

Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death. Preventing the occurrence of these arrhythmias is a major challenge. This study aims to investigate risk factors and protective factors regarding atrial fibrillation and other iatrogenic cardiac arrhythmias after cardiac surgery, particularly innovative anesthetic strategies such as stellar ganglion blockade which have been recently implemented in our center.

Participants needed: 918
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Centre Hospitalier Régional Metz-ThionvilleUpdated: Jun 25, 2026Locations: 1
Eligibility criteria

age >18 [+2]

Atrial fibrillation at the admission in hospital.

Status: Not yet recruiting

Optimized Novel Wireless Assessment of Respiratory and Circulatory Dirstress - Alarm Validation

The ONWARD study evaluates user experiences from continuous vital sign monitoring alarms sent to the clinical staff in case of deviating vital signs at the general hospital ward. User experiences are evaluated though a 5-point likert questionnaire.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Eske Kvanner AasvangUpdated: Jun 16, 2026Locations: 2
Eligibility criteria

Age ≥ 18 years [+2]

Having implanted electronic devices (such as pacemaker or Implantable Cardiovert... [+3]

Status: Not yet recruiting

Neurocognitive Loading Following Anterior Shoulder Stabilization: A Randomized Controlled Trial

The goal of this randomized controlled clinical trial is to learn if adding neurocognitive loading to standard shoulder rehabilitation improves physical and psychological recovery in adults who have undergone arthroscopic anterior shoulder stabilization surgery (such as Bankart repair, Latarjet, or remplissage procedures). The main questions it aims to answer are: Does adding neurocognitive loading exercises improve shoulder proprioception, muscle strength, and functional performance compared to standard therapy alone? Does this integrated training approach reduce the kinesiophobia? Does it lead to better overall clinical outcomes and improve psychological readiness to return to sports? Researchers will compare a group receiving standard shoulder exercises combined with dual-task neurocognitive loading (using light-based reaction systems and cognitive tasks) to a control group receiving standard shoulder rehabilitation alone. Participants will:Undergo supervised physical therapy sessions starting 10 days after surgery up to the 16th postoperative week (twice a week for the first 12 weeks, and once a week for weeks 13-16) alongside an assigned home exercise program. Complete neurocognitive loading tasks (if assigned to the intervention group) that challenge attention, quick decision-making, and visual reactions while executing physical movements. Attend detailed clinical evaluation sessions lasting about 60 minutes before the treatment starts, and at 6, 12, and 24 weeks after surgery. These assessments include neurocognitive, functional and clinical tests, and questionnaires.

Participants needed: 32
Trial details
Age: 18-45Biological sex: AllType: InterventionalSponsor: Hacettepe UniversityUpdated: Jun 8, 2026
Eligibility criteria

Age: Participant must be between 18 and 45 years of age. [+4]

Hypermobility: Diagnosed generalized joint hypermobility syndrome, defined as a... [+10]

Status: Not yet recruiting

Postoperative Vaginal Compression After Prolapse Surgery - an RCT

The goal of this clinical trial is to learn if omitting postoperative vaginal compression (packing) can facilitate a more efficient recovery after elective surgery for uterovaginal prolapse. The main questions it aims to answer are: Will the omission of vaginal compression result in a non-inferior (unchanged) rate of prolapse recurrence within the first three months after surgery? Does the omission of vaginal compression lead to a shorter hospital stay and a faster return of normal bladder function? Researchers will compare a group that receives no postoperative vaginal compression to a control group that receives standard vaginal gauze packing for two hours to see if skipping the packing leads to shorter hospital stays and faster bladder emptying without increasing the risk of the prolapse returning.

Participants needed: 360
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Christiane Marie Bourgin Folke GamUpdated: May 28, 2026Locations: 1
Eligibility criteria

Planned anterior colporrhaphy, posterior colporrhaphy, or cervical amputation at... [+2]

Failure to pause blood-thinning medication on the day of surgery, if this was pl... [+5]

Status: Recruiting

Multimodal AI-Guided Recovery Management After Lung Cancer Surgery

This study is a multicenter, prospective, randomized controlled trial designed to evaluate the effectiveness and safety of a multimodal artificial intelligence (AI)-guided postoperative recovery management system in patients after lung cancer surgery. Eligible patients will be enrolled after surgery when their clinical condition is stable and will be randomly assigned to either an AI-guided recovery management group or a usual postoperative care group. Patients in the AI-guided group will receive usual postoperative care plus a multimodal AI-based recovery management system. The system will collect patient-reported symptoms, vital signs, physical activity, respiratory rehabilitation information, recovery-related data, and, when needed, wound or chest-related images or short videos. Based on these data, the system will provide recovery feedback, general nursing advice, respiratory rehabilitation reminders, activity guidance, and risk stratification alerts. For red-flag symptoms or high-risk conditions, the system will advise patients to contact the clinical team or seek medical care. Patients in the usual-care group will receive standard postoperative management after lung cancer surgery and will complete symptom assessments at the same prespecified time points, but they will not receive AI-generated individualized recovery feedback or AI-generated risk alerts. The primary outcome is the number of MDASI-LC-derived target symptom threshold events within 30 days after surgery. Target symptoms include pain, fatigue, disturbed sleep, shortness of breath, and cough. Secondary outcomes include overall target symptom burden, quality of recovery, time to recovery to a mild-symptom state, functional interference, respiratory rehabilitation adherence, physical activity adherence, unplanned healthcare utilization, pulmonary complications, and unplanned readmission.

Participants needed: 868
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: The First Affiliated Hospital of Guangzhou Medical UniversityUpdated: May 15, 2026Locations: 1
Eligibility criteria

Age 18 years or older. [+8]

Patients receiving non-surgical treatment only. [+7]

Status: Not yet recruiting

Empowering Families in Pediatric Cardiovascular Surgery: A RAM-Based Approach

The purpose of this clinical trial is to learn about the effects of a nursing support program designed for families of children aged 1 to 3 years who have undergone heart surgery. This program aims to improve parents' caregiving skills and support the healthy growth of their children. The primary questions the study aims to answer are: Does the nursing program positively affect the physical growth of children, such as their height and weight? Does the program improve children's scores on general development tests (Denver II)? Do parents' attitudes toward child feeding and their confidence in parenting skills increase? Researchers will divide participants into two groups: Experimental Group: Families who participate in the nursing education program and receive an informative booklet. Control Group: Families who only receive an informative booklet and continue with routine hospital follow-ups. The researchers will compare these two groups to see if participating in the nursing program leads to better results for the children's development and the families' skills. Participants will be asked to: Attend 5 different education and counseling sessions, starting one week before surgery and continuing until the child reaches 1 year of follow-up. Meet with the researcher at specific intervals (at 1, 2, 3, 6, 9, and 12 months) for one year to monitor the child's development (height, weight, head circumference) and skills. Complete surveys regarding child feeding attitudes and parenting skills at the 6th and 12th month follow-ups.

Participants needed: 80
Trial details
Age: 1-3Biological sex: AllType: InterventionalSponsor: Cukurova UniversityUpdated: May 12, 2026Locations: 3
Eligibility criteria

Families who agree to participate in the study and sign the informed consent for... [+3]

Exclusion criteria include the presence of additional congenital malformations,...

Status: Recruiting

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

Postoperative pain is prevalent after intracranial surgery. Patients undergoing craniotomy are typically managed with short acting opioids to enable early and reliable post-operative neurological exam as well as avoid the risk of respiratory depression. However, a plethora of studies have shown that a majority of these patients experience moderate to severe pain in first 48 hours after surgery. Suboptimal pain control can lead to complications such as arterial hypertension and post-operative intracranial hemorrhage, and hence, increased morbidity and mortality. Intravenous (IV) methadone has a long analgesic half-life and has N-methyl-D-aspartate (NMDA) receptor antagonist and serotonin and norepinephrine reuptake inhibitor (SNRI) properties. It has previously been shown to reduce postoperative opioid requirements, postoperative nausea and vomiting (PONV), and postoperative pain scores in patients that underwent orthopedic, abdominal, complex spine, and cardiac surgery. Similar findings have been shown in obstetric patients that underwent caesarean delivery under general anesthesia as well as patients that underwent gynecologic surgery and received IV methadone intraoperatively. In a recently published retrospective study, a single intraoperative dose of IV methadone was well tolerated with lower pain scores as well as MME (oral morphine milligram equivalents) requirements for up to 72 hours after elective intracranial surgery. IV methadone has, however, never been compared with conventional management via IV remifentanil for functional recovery in patients undergoing elective intercranial surgery. The investigator's hypothesis is that intravenous (IV) methadone is non-inferior to IV remifentanil in patients who undergo elective intracranial surgery. It offers the advantage of being a single dose noninvasive analgesic modality that may contribute to decreasing MME consumption during the first 72 hours postoperatively, controlling postoperative pain, and improving quality of recovery after surgery.

Participants needed: 40
Trial details
Phase: Early Phase 1Age: 18-65Biological sex: AllType: InterventionalSponsor: University of VirginiaUpdated: May 4, 2026Locations: 1
Eligibility criteria

Adult Patients between ages 18 and 65 years old. [+4]

Being unable or unwilling to sign a consent [+11]

Status: Not yet recruiting

Rocking Chairs as Post-operative Treatment for Older Adults After Hip Surgery

Feasibility and acceptability randomized controlled trial exploring the use of a rocking chair after a total hip arthroplasty in adults who are aged 65 or older. Primary aims include its feasibility and acceptability; exploratory aims include the impact of rocking on pain, gastrointestinal effects, anxiety, ambulation, and additional healthcare visits.

Participants needed: 60
Trial details
Age: 65+Biological sex: AllType: InterventionalSponsor: University of Missouri, Kansas CityUpdated: Apr 27, 2026
Eligibility criteria

scheduled to undergo an elective primary total hip arthroplasty [+3]

Unable to sit in a chair for at least 30 minutes at a time [+4]

Status: Recruiting

Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery

The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.

Participants needed: 60
Trial details
Phase: Phase 4Age: 6-4Biological sex: AllType: InterventionalSponsor: Duke UniversityUpdated: Apr 14, 2026Locations: 1
Eligibility criteria

Age 6 months to 4 years of age [+2]

History of chronic kidney or liver disease [+3]

Status: Not yet recruiting

CABG-AI-Supported Discharge Education

This randomized controlled trial will evaluate the effectiveness of artificial intelligence-supported individualized discharge education for patients undergoing coronary artery bypass graft (CABG) surgery. Participants will be assigned to either the intervention group, which will receive personalized AI-generated discharge education delivered through a nurse-avatar video in addition to standard verbal education, or the control group, which will receive standard discharge education only. The study will compare postoperative pain, anxiety, physiological stress response, recovery, and satisfaction with discharge education between the two groups. Outcomes will be measured during hospitalization and at the routine postoperative follow-up visit. The findings may help improve patient education methods and postoperative recovery in cardiac surgery patients.

Participants needed: 128
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Hasan Kalyoncu UniversityUpdated: Mar 31, 2026
Eligibility criteria

Patients who have undergone coronary artery bypass graft (CABG) surgery. [+6]

Patients undergoing emergency CABG surgery. [+8]

Status: Not yet recruiting

Effect of Postoperative Holistic Nursing Care on Children's Satisfaction and Nursing Image Perception

This randomized controlled study aims to evaluate the effect of holistic nursing care applied during the postoperative period on children's satisfaction with care and their perception of nursing image. The study will be conducted in the Pediatric Surgery Clinic of Antalya Training and Research Hospital with children aged 8 to 11 years who undergo surgical procedures. Participants will be randomly assigned to either an intervention group or a control group. All children will receive routine postoperative nursing care. In addition to routine care, children in the intervention group will participate in a mandala coloring activity accompanied by music. This supportive activity is designed to help children relax, express their feelings, and improve their hospital experience. Data will be collected using standardized questionnaires that measure children's satisfaction with nursing care and their perception of nurses. The study aims to determine whether holistic nursing practices can improve children's satisfaction and positively influence how they perceive the nursing profession.

Participants needed: 70
Trial details
Age: 8-11Biological sex: AllType: InterventionalSponsor: Akdeniz UniversityUpdated: Mar 9, 2026Locations: 1
Eligibility criteria

Children aged 8 to 11 years [+5]

Cognitive impairment preventing completion of questionnaires [+3]

Status: Recruiting

Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current accepted management.

Participants needed: 50
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Alexander T. YahandaUpdated: Feb 20, 2026Locations: 1
Eligibility criteria

Long-segment spinal fusions (defined as constructs spanning at least L2-pelvis f... [+1]

Patients <18 years of age [+6]

Status: Recruiting

Nutrition to Support Postoperative Recovery

Older surgical patients commonly have malnutrition, and there is evidence these patients have increased risk for poor physical and brain recovery after surgery and anesthesia. There are scientific-based recommendations to provide nutritional supplements to support recovery. However, to date these recommendations do not address a broad group of nutrients likely to reverse common deficiencies. Team members have created a palatable, broad-spectrum and stable nutritional shake that we will give to patients after surgery. We propose to test the nutritional shake in frail older surgical patients at Dartmouth Health to determine if a nutrition shake provided after surgery improves recovery of physical function and cognitive abilities. Half the patients will receive the shake and the other will receive the standard of care postoperative nutritional instructions after surgery. We will collect information regarding physical function and cognitive abilities of all the patients while in the hospital and 90 days after surgery. We will use this data to apply for funding for a powered randomized trial to determine the role of nutrition in optimizing physical and cognitive recovery from surgery in older patients.

Participants needed: 100
Trial details
Age: 70+Biological sex: AllType: InterventionalSponsor: Dartmouth-Hitchcock Medical CenterUpdated: Feb 11, 2026Locations: 1
Eligibility criteria

patients >=70 years old having major orthopedic or abdominal surgery, defined as...

emergency surgery, diagnosis of dementia or major psychiatric diagnosis such as... [+1]

Status: Recruiting

Multisensory and Cognitive Interventions in the ICU: Effects on Health and Recovery

The goal of this clinical trial is to examine the effects of sensory and cognitive stimulation on physiological, psychological, and functional recovery in adult patients after cardiac surgery who are treated in the intensive care unit (ICU). The main questions it aims to answer are: * Does sensory and/or cognitive stimulation reduce anxiety and improve hemodynamic stability in ICU patients? * Does it enhance physical function and independence during early rehabilitation in the ICU? Researchers will compare four groups: 1. Standard care (control), 2. Cognitive stimulation, 3. Auditory stimulation (music), 4. Multisensory stimulation (touch + smell) to assess which intervention is most effective in improving recovery parameters. Participants will: * Be randomly assigned to one of four groups during early mobilization in the ICU * Receive a 30-minute intervention session depending on group assignment * Be evaluated for heart rate, blood pressure, oxygen saturation, anxiety (VAS), physical function (PFIT, FIM), and satisfaction before and after the session

Participants needed: 125
Trial details
Age: 18-80Biological sex: AllType: InterventionalSponsor: Abant Izzet Baysal UniversityUpdated: Feb 12, 2026Locations: 1
Eligibility criteria

Age between 18 and 80 years [+4]

Diagnosis of ICU delirium or altered mental status [+4]

Status: Not yet recruiting

Nurse-Led Early Mobilization After Colorectal Surgery

This study was designed to evaluate the effectiveness of a nurse-led early mobilization protocol on postoperative recovery outcomes in patients undergoing elective colorectal surgery. The outcomes assessed include walking distance, mobility levels, gastrointestinal function (time to first flatus and first defecation), nausea, vomiting, comfort, fatigue, time to initiation of oral intake, patient satisfaction, incidence of postoperative complications, and length of hospital stay. Research Question: In patients undergoing colorectal surgery (P), does a nurse-led early mobilization protocol (I), compared with standard mobilization practices (C), improve postoperative recovery outcomes (O), including walking distance, mobility levels, gastrointestinal function (time to first flatus and first defecation), nausea, vomiting, comfort, fatigue, time to initiation of oral intake, patient satisfaction, postoperative complication rates, and length of hospital stay?

Participants needed: 80
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Ege UniversityUpdated: Jan 28, 2026Locations: 1
Eligibility criteria

Adults aged 18 years and older [+5]

Undergoing emergency colorectal surgery [+4]

Status: Not yet recruiting

Complications of Surgical Geriatrics Hospitalized in the Orinoco Region

The life expectancy of the Colombian population is increasing. Older patients are frequently hospitalized and treated in surgical wards, and are treated as the general surgical population. However, geriatric patients are frequently found with additional comorbidities, besides the primary surgical diagnosis. Some diseases, like hip fractures, diverticulitis, and cancer, are common in this age range. The preoperative, intraoperative, and postoperative period requires a special care and planning to avoid complications related to the physical status, medications, and comorbidities. Studies about the geriatric surgical population are limited in the Orinoco region. The implementation of a comprehensive geriatric assesment in surgical services requires follow-up of outcomes.

Participants needed: 150
Trial details
Age: 18-100Biological sex: AllType: ObservationalSponsor: Hospital Departamental de VillavicencioUpdated: Jan 28, 2026Locations: 1
Eligibility criteria

Adults [+2]

Derived to other institution [+1]

Status: Recruiting

Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis

Investigators tried to evaluate the efficacy and safety of Chinese herbal medicine nasal irrigation as an adjuvant therapy after FESS.

Participants needed: 80
Trial details
Phase: Phase 2Age: 18-90Biological sex: AllType: InterventionalSponsor: Taichung Veterans General HospitalUpdated: Jan 14, 2026Locations: 1
Eligibility criteria

1. Patients with chronic rhinosinusitis who failed medical treatment 2.Patients...

1. Patients with a history of immunodeficiency 2.Patients with a history of sinu...

Status: Not yet recruiting

Prevention of Rebound Pain After Axillary Block

This will be a single-center randomized double blind placebo control clinical trial. In the cohort of patients undergoing hand surgery under axillary nerve block, participants are recruited from those who are willing to consent and participate in the study, and will be randomly 1:1 divided into intervention group and placebo group.

Participants needed: 60
Trial details
Age: 18-75Biological sex: AllType: InterventionalSponsor: University Tunis El ManarUpdated: Jan 2, 2026
Eligibility criteria

• Age between 18 and 75 years old. [+2]

- Contraindication to regional anesthesia. [+4]

Status: Not yet recruiting

Romanian Validation and Cross-cultural Adaptation of the QoR-15Ro

Optimal postoperative recovery after any surgical procedure requiring anesthesia is essential to achieving high-quality care. The Quality of Recovery questionnaire (QoR-15) was validated by its authors in 2013 in the study "Development and psychometric evaluation of a postoperative quality of recovery score: the QoR-15." This instrument enables a comprehensive evaluation by integrating traditional physiological measures with the patient's subjective perception of their health status. With the consent of the original author, the present study aims to validate the Romanian version of the questionnaire and adapt it to our clinical environment.

Participants needed: 250
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: SUUMC Central Military Hospital Dr Carol DavilaUpdated: Dec 8, 2025Locations: 1Duration: 15 Days
Eligibility criteria

Patients over 18 years old. [+4]

Patients under 18 years old. [+4]

Status: Recruiting

Machine Learning for Predicting Spinal Anesthesia Duration

Spinal anesthesia provides significant advantages over general anesthesia in knee arthroplasty, including reduced blood loss, faster recovery, and fewer complications. However, predicting its duration is critical for patient safety and effective postoperative management. This study evaluates the usability of machine learning (ML) algorithms to predict the termination time of spinal anesthesia and the patient's readiness for mobilization. Using demographic, surgical, and anesthetic variables, ML models were trained to estimate anesthesia duration. Accurate predictions may improve intraoperative planning, optimize postoperative care, and enhance patient outcomes. Integrating ML-based predictive systems into anesthesia practice can contribute to safer, more efficient, and personalized perioperative management.

Participants needed: 140
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Kocaeli City HospitalUpdated: Dec 8, 2025Locations: 1
Eligibility criteria

Patients scheduled to undergo total knee arthroplasty between November 2025 and... [+4]

Patients who were converted to general anesthesia during surgery or initially op... [+4]

Status: Not yet recruiting

Posthectomy in Pediatric Elective Surgery : a Comparison of Perioperative Analgesia Using Echo-guided Penile Block and Pudendal Block With neurostimuLation Technique

Context : Posthectomy is a surgical procedure that concerns around 30% of the male population, mainly in pediatrics. As this procedure is mainly performed on an outpatient basis, the implementation of an enhanced rehabilitation protocol after surgery in pediatrics helps to reduce the incidence of postoperative pain, notably by providing multimodal analgesia, including locoregional anesthesia. Current recommendations from pediatric locoregional anesthesia societies favor penile block and the use of ultrasound in pediatric anesthesia to reduce anesthetic set-up time and the volume of local anesthetic, but also to increase the duration of sensory block and the success rate. However, several studies have shown the inferiority of penile block in anatomical landmarks compared with pudendal block under neurostimulation. As a result, pediatric anesthesiologists at Caen University Hospital prefer to use pudendal blocks under neurostimulation for posthectomy surgery. To date, no study has compared penile block under ultrasound with pudendal block under neurostimulation for postoperative analgesia after posthectomy surgery. On the other hand, a study of postoperative analgesia in hypospadias surgery showed a clear superiority of penile block under ultrasound over pudendal block in terms of both immediate postoperative pain and duration of postoperative analgesia. It therefore seems pertinent to compare these two techniques in posthectomy surgery. Objective: We propose a prospective, open-label, non-inferiority study with the primary objective of comparing the efficacy of echo-guided penile block versus pudendal block in neurostimulation for posthectomy surgery. Methods: This randomized, single-center study will include 240 patients divided into two groups. The experimental group will receive optimized medical and surgical management, with a penile block under ultrasound, while the control group will receive a pudendal block under neurostimulation. The planned duration of the study is 3 years. Hypothesis tested: We hypothesize that ultrasound-guided penile block is non-inferior to neurostimulated pudendal block for postoperative analgesia in scheduled posthectomy surgery. The secondary objectives are to evaluate the time taken to perform the block, the volume of local anesthetic used, the need for sufentanil reinjection intraoperatively, the quantitative evaluation of analgesia using the EVENDOL score, the consumption of nalbuphine in the post anesthesia care unit, the occurrence of postoperative vomiting, and the length of stay in the post anesthesia care unit. The rate of complications related to the performance of locoregional anesthesia is also observed.

Participants needed: 240
Trial details
Age: 12-18Biological sex: MaleType: InterventionalSponsor: University Hospital, CaenUpdated: Sep 25, 2025Locations: 1
Eligibility criteria

All children aged over 3 months or 60 weeks post-conceptional age scheduled for...

Recent airway infection. [+5]

Status: Recruiting

Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia

Currently the prevalent approach to perioperative management of patients is ERAS (Enhanced Recovery After Surgery) concept. This approach includes numerous aspects, among which the perioperative use of multimodal analgesia takes one of the leading places. Within the ERAS guidelines all sorts of minimization of opioid analgesics use in schemes of postoperative analgesia are appreciated. Thus, new pharmacological approaches are being actively developed currently in order to achieve adequate analgesia and to minimize the use of this group of drugs. One of the most perspective trends within the multimodal analgesia concept is continuous infusion of non-steroidal anti-inflammatory drugs (NSAID). Up to date there are papers that both confirm the effectiveness of this method for maintaining adequate postoperative analgesia and show its limitations and deny the advantages of the continuous use of NSAID. Up to this time the main attention of the medical community was paid for such drugs as paracetamol and ketoprofen. Nevertheless, one of the most common and safe NSAID is ibuprofen. In spite of this, there are no studies that explore the effectiveness of the continuous infusion of this drug. Thus, the lack of even low-quality evidence led to setting up a study of effectiveness and safety of continuous infusion of ibuprofen in comparison to its bolus injection.

Participants needed: 100
Trial details
Phase: Phase 4Age: 18+Biological sex: AllType: InterventionalSponsor: Federal Research and Clinical Centre of Intensive Care Medicine and RehabilitologyUpdated: Jul 17, 2025Locations: 1
Eligibility criteria

Age > 18 years old [+4]

History of ibuprofen allergy [+7]

Status: Not yet recruiting

Digital Aftercare for Wrist and Clavicle Fractures

This prospective, two-arm, open-label clinical trial compares digital aftercare with traditional follow-up in adult patients after surgical treatment of uncomplicated distal radius or clavicle fractures. The primary objective is to assess functional recovery at three months, using the Patient-Rated Wrist Evaluation (PRWE) for wrist fractures and the QuickDASH for clavicle fractures. Secondary outcomes include range of motion, patient satisfaction, quality of life, complication rates, healthcare costs, and work disability. In the digital aftercare group, program adherence and user experience will also be evaluated through app usage data and a structured questionnaire. The study aims to determine whether digital aftercare is a clinically and economically equivalent alternative to standard in-person care.

Participants needed: 84
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Luzerner KantonsspitalUpdated: Jul 8, 2025Locations: 1
Eligibility criteria

Age between 18 and 65 years [+4]

Polytrauma or additional injuries to the same upper extremity [+4]

Status: Not yet recruiting

Impact of Pre-anesthetic Evaluation on the Anxiety

Since the last century, it has been understood that "the pre-anesthetic evaluation is the patient's right and the anesthesiologist's duty." As early as 2006, the Conselho Federal de Medicina (CFM) published a resolution addressing the anesthetic act and guiding the conduct of pre-anesthetic evaluation (PAE) and in 2017 revised these guidelines in a new resolution. The PAE is an important step in preparing the patient for elective surgical procedures. It refers to the moment when the anesthesiologist and patient have the opportunity to get to know each other, optimize the patient's clinical conditions and even request exams or consult other specialists when necessary. The prevalence and levels of anxiety, commonly generated by the expectation of the surgical-anesthetic procedure, tend to reduce with the PAE. This leads to fewer patients presenting to the operating room with arterial hypertension or arrhythmia, which are triggered by anxiety. It can be said that the implementation of the PAE directs screening processes and consequently reduces the patient's risk to unnecessary procedures or consultations. It also highlights the reduction in perioperative morbidity and mortality rates. By analyzing the dynamics of the surgical center, where the space is highly technological and contested by various surgical specialties, it is possible to associate the PAE with the reduction in cancellation rates of procedures and the proper use of space. Measuring sentiment is difficult and to assess anxiety, one can use complex questionnaires to small and objective scales. Some studies show how anxiety can contribute to increased postoperative pain, higher medication consumption, and longer hospitalization time. A possible tool to change this scenario would be the PAE, but its relationship with anxiety still needs to be further documented, especially in Brazil. Therefore, this project seeks to study the hypothesis that the PAE reduces anxiety levels, brings quality to the anesthetic-surgical experience, and improves perioperative morbidity indicators. This study aims to evaluate the impact of pre-anesthetic evaluation on perioperative surgical outcomes in patients of the orthopedic specialty undergoing procedures at the institution. It aims to identify the anxiety level of patients undergoing orthopedic surgery. This randomized clinical trial will be conducted at the Hospital de Base do Distrito Federal, Brasília, Distrito Federal, Brazil.

Participants needed: 100
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Hospital de BaseUpdated: Jun 22, 2025
Eligibility criteria

elective or urgent orthopedic surgery [+2]

Patient refusal to participate [+7]