Primary Dysmenorrhea (PD)

6

Review clinical trials related to Primary Dysmenorrhea (PD). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Effect of Pilates Exercises Versus Gym Exercises On Primary Dysmenorrhea

This study will be conducted to assess the effect of Pilates Exercises Versus Gym Exercises On Primary Dysmenorrhea.

Participants needed: 52
Trial details
Age: 17-25Biological sex: FemaleType: InterventionalSponsor: Cairo UniversityUpdated: Jun 25, 2026
Eligibility criteria

Their ages will be ranged from 17-25 years old [+2]

Females will be excluded from the study if they have; [+4]

Status: Not yet recruiting

Effect of Semiconductor Embedded Wearable Sleeve on Treatment of Primary Dysmenorrhea Symptoms

This study is looking to test a non-compressive semiconductor embedded body sleeve for treatment of primary dysmenorrhea symptoms. Dysmenorrhea is the lower abdominal pain (sometimes referred to as "cramping") experienced during menstruation (monthly "period"), affecting up to 94% of people aged from 10-20 years old. The semiconductor embedded fabric increases blood circulation through activation of the embedded elements with body heat while worn and releases energy waves as well as negative ions. This energy has an effect inside the body that increases oxygen and nutrient flow to tissues, and can help to decrease pain and inflammation. This study is testing this technology to see if it can be used as a non-pharmacological treatment for menstrual cramping.

Participants needed: 100
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: University of California, DavisUpdated: Jun 16, 2026
Eligibility criteria

Self-reported primary dysmenorrhea during past three menstrual cycles [+4]

History of neurological conditions, including multiple sclerosis or Parkinson's... [+16]

Status: Recruiting

Graded Motor Imagery for Primary Dysmenorrhea

The goal of this clinical trial is to learn if graded motor imagery can reduce pain sensitivity and period pain in women with primary dysmenorrhea (painful periods with no medical cause). The main questions it aims to answer are: 1. Is there a decrease in pressure pain threshold (increased pain sensitivity) with graded motor imagery? 2. Is the intensity of menstrual pain reduced by graded motor imagery? 3. Is GMI helpful to reduce menstrual symptoms and pain catastrophizing (negative thinking about pain)? Researchers will compare full GMI (active intervention), a sham GMI(inactive intervention), and a wait-list (no intervention) to see if GMI works better than the alternatives. Participants will: 1. Take part in a 6-week graded motor imagery program, sham program, or no intervention control. 2. Do laterality recognition, motor imagery, and mirror therapy exercises in the graded motor imagery group. 3. Complete pain and symptom assessments before and after the program, and again at follow-up.

Participants needed: 81
Trial details
Age: 18-30Biological sex: FemaleType: InterventionalSponsor: Dr. Mehak NaeemUpdated: Jun 2, 2026Locations: 1
Eligibility criteria

Female sex (aged 18-30 years) [+6]

Secondary dysmenorrhea (endometriosis, adenomyosis, fibroids, pelvic inflammator... [+8]

Status: Recruiting

Pelvic Nerve Mobilization for Primary Dysmenorrhea

Primary dysmenorrhea is a highly prevalent condition among young women and is associated with significant pain, reduced quality of life, and academic absenteeism. Although non-steroidal anti-inflammatory drugs are commonly used, many women seek non-pharmacological alternatives due to limited effectiveness or adverse effects. Emerging evidence suggests that altered pelvic neurodynamics may contribute to dysmenorrheic pain. This randomized controlled trial aims to evaluate the effectiveness of external pelvic nerve mobilization in reducing menstrual pain and associated symptoms among university women with primary dysmenorrhea. Participants aged 18-30 years will be randomly allocated to receive either external pelvic nerve mobilization or a sham manual therapy intervention across three consecutive menstrual cycles. Outcomes will include pain intensity, menstrual distress, quality of life, pelvic tenderness, analgesic consumption, and academic absenteeism.

Participants needed: 60
Trial details
Age: 18-30Biological sex: FemaleType: InterventionalSponsor: University of HailUpdated: Apr 29, 2026Locations: 1
Eligibility criteria

Female university students aged 18-30 years [+4]

Secondary dysmenorrhea (e.g., endometriosis, fibroids, pelvic inflammatory disea... [+5]

Status: Not yet recruiting

Effect of Yoga Training on Nausea and Pain

This study was planned to determine the effect of yoga training on reducing nausea and pain symptoms in young women with primary dysmenorrhea. As a result of this study, evaluating the extent to which women with dysmenorrhea experience pain and nausea and the extent to which yoga has a positive effect on these symptoms may shed light on women experiencing these symptoms and developments in the literature, and may increase the use of non-pharmacological approaches. The results of the study will contribute to the literature on dysmenorrhea, one of the important gynecological problems in women. In addition, although there are many results in the literature on the effectiveness of yoga in the management of nausea symptoms with cancer patients, there are not many studies on nausea on dysmenorrhea. In this respect, it will provide important evidence to the literature.

Participants needed: 70
Trial details
Age: 18-30Biological sex: FemaleType: InterventionalSponsor: Çankırı Karatekin UniversityUpdated: Jun 3, 2025Locations: 1
Eligibility criteria

Having a regular menstrual cycle [+4]

Wanting to leave the study, primary dysmenorrhea severity and nausea level below...

Status: Not yet recruiting

A Preliminary Study on the Efficacy of Danggui Shaoyao San and Cuscuta Chinensis in Patients with Primary Dysmenorrhea

This study aims to evaluate the efficacy of two traditional Chinese medicine (TCM) formulas, Danggui Shaoyao San (DSS) and Cuscuta Chinensis (Tu Si Zi), in treating primary dysmenorrhea (PD). Primary dysmenorrhea, a common condition characterized by painful menstrual cramps, affects many women of reproductive age and significantly impacts their quality of life. Conventional treatments, such as NSAIDs and oral contraceptives, often have limited efficacy or side effects, underscoring the need for alternative therapeutic options. In this randomized, double-blind study, participants will be divided into four groups: DSS, Tu Si Zi, a combination of DSS and Tu Si Zi, and a placebo group. The study will measure treatment outcomes using the Visual Analogue Scale (VAS) for pain and the Menstrual Symptom Questionnaire (MSQ), which captures physical and emotional symptoms. Additionally, TCM-based tools like pulse diagnosis and constitution questionnaires will be employed to explore personalized treatment strategies. This research seeks to determine whether these TCM formulas can alleviate pain and improve other menstrual symptoms, potentially providing broader benefits than conventional painkillers. The findings aim to support evidence-based integration of TCM in managing dysmenorrhea and inform clinicians and patients about effective therapeutic choices.

Participants needed: 200
Trial details
Age: 20-45Biological sex: FemaleType: InterventionalSponsor: Taichung Tzu Chi HospitalUpdated: Dec 12, 2024Locations: 1
Eligibility criteria

Female participants aged 20 to 45 years. [+4]

Secondary dysmenorrhea caused by conditions such as endometriosis, pelvic inflam... [+8]