Primary Health Care

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Review clinical trials related to Primary Health Care. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

The REACH-OUT Trial

Test the effectiveness of a technology-enabled strategy to optimize blood pressure among reproductive-aged women with hypertension receiving care in Federally Qualified Health Centers.

Participants needed: 350
Trial details
Age: 18-44Biological sex: FemaleType: InterventionalSponsor: Northwestern UniversityUpdated: Jun 22, 2026Locations: 1
Eligibility criteria

biologically female [+5]

not pregnant or within 3 months postpartum [+1]

Status: Recruiting

Aconselha + Movimento: Protocol for Online Training on Physical Activity and Sedentary Behavior Counseling

This study aims to develop, implement, and evaluate the effectiveness of an online training program on physical activity and sedentary behavior counseling for primary health care workers. The training program is designed to improve competencies related to physical activity and sedentary behavior counseling within primary health care settings. Health professionals working in primary health care units from selected municipalities in Brazil will be invited to participate. Outcomes related to counseling competencies and professional practices will be assessed before and after participation in the training program.

Participants needed: 3,306
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Universidade Federal do ParanáUpdated: Jun 9, 2026Locations: 3
Eligibility criteria

Healthcare professionals working in Primary Health Care Units (UBS) in Florianóp... [+2]

Professionals who are not actively working during the data collection period [+2]

Status: Not yet recruiting

District Health Centre Membership Among Older Adults in Hong Kong

This study is a cluster randomized controlled trial study to evaluate the feasibility, acceptability, and effectiveness of intergenerational home-based and AI-generated digital interventions in improving the proportion of District Health Centre members among older adults in Hong Kong.

Participants needed: 180
Trial details
Age: 65+Biological sex: AllType: InterventionalSponsor: The University of Hong KongUpdated: Apr 29, 2026Locations: 1
Eligibility criteria

65 years or older [+4]

All subjects have the right to withdraw if they wish not to continue

Status: Recruiting

Generative AI Plan for Care Lab Study

This is an experimental study to observe participants' interactions with the Pre-visit Lab, and the output of various generative AI models that support consumer symptom queries and provide the user with information about possible urgency, potential causes or diagnoses based on the symptoms they disclose, and a summary of information to bring to a health care visit if planned.

Participants needed: 40,000
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Fitbit LLCUpdated: Apr 27, 2026Locations: 1
Eligibility criteria

Age of majority: are of legal adult age (18 or older in most US states; 19 or ol... [+3]

Enrollment using a corporate google.com account [+2]

Status: Not yet recruiting

Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy

This multicenter pilot study evaluates the feasibility, implementation fidelity, and preliminary effects of the GAP-421 (Personalized Care Management) model for chronic pain management in primary care physiotherapy. The GAP model is a time-limited organizational modality that reconfigures schedules, resources, and professional roles during a defined 6-week window to organize care around the individual patient and their trajectory, formalizing coordination work that previously occurred informally. The study uses a convergent mixed-methods design across three primary care health centers in the Southeast Healthcare District (DASE) of the Community of Madrid, Spain. The quantitative component is a prospective multicenter pre-post case series with 3-month follow-up (n=66 patients, 22 per center). The qualitative component includes semi-structured interviews (n=12) and focus groups (3 groups, n=6 each). Integration occurs through Joint Display, Pillar Integration Process, and a 9-type legitimation framework. The primary outcome is patient-perceived care coordination measured on a 0-10 numerical scale (PREM). Secondary outcomes span five domains: patient-reported outcomes (EQ-5D-5L, Graded Chronic Pain Scale, pain intensity), professional outcomes (coordination burden, role clarity), system sustainability (avoidable re-consultations, emergency department use), implementation fidelity, and feasibility indicators. Results will generate feasibility parameters, intraclass correlation coefficient estimates, and process indicators essential for designing definitive cluster-randomized trials testing organizational interventions in primary care physiotherapy.

Participants needed: 66
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Universidad Autonoma de MadridUpdated: Mar 5, 2026Locations: 2
Eligibility criteria

Adults aged 18 years or older [+4]

Active cancer pain [+6]

Status: Not yet recruiting

Enhancing Mental and Physical Health of Women Veterans 3.0

Women Veterans are the fastest growing segment of VA users, with most users in midlife. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. Furthermore, few VA improvement efforts have focused on women Veterans' health and health care in midlife. The EMPOWER QUERI 3.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in at least 18 VA facilities from 4 regions.

Participants needed: 18
Trial details
Biological sex: AllType: InterventionalSponsor: VA Office of Research and DevelopmentUpdated: Jan 21, 2026Locations: 1
Eligibility criteria

This study is recruiting VA sites - not individual patients. [+1]

N/A

Status: Recruiting

Promoting Preconception Care and Diabetes Self-Management Among Reproductive-Aged Women With Diabetes

This study is being done to investigate strategies that may improve patient's knowledge of type 2 diabetes during reproductive age and improve knowledge and engagement in self-care activities.

Participants needed: 840
Trial details
Age: 18-44Biological sex: FemaleType: InterventionalSponsor: Northwestern UniversityUpdated: Nov 18, 2025Locations: 1
Eligibility criteria

female [+6]

severe, uncorrectable vision, hearing, or cognitive impairments that would precl...

Status: Not yet recruiting

Online Access to Clinical Treatment Notes for Outpatients

This study investigates the feasibility and impact of patient access to clinical notes written by their healthcare providers-a concept known as Open Notes. While international research has already demonstrated positive effects of Open Notes on patient empowerment and treatment outcomes, there is a lack of corresponding evidence for the German healthcare context. The quasi-experimental study therefore combines quantitative and qualitative methods to evaluate the effects of Open Notes on patient-reported outcomes as well as clinical practice. The study is structured into five modules, each addressing specific research questions: Module A - Summative Outcome Evaluation in Patients: Does the use of Open Notes lead to a significant increase in patient-reported outcomes such as empowerment and self-efficacy? Module B - Formative Process Evaluation with Stakeholders: What experiences do patients, relatives and clinicians have with Open Notes and what challenges and barriers arise in their use? Module C - Changes in Clinical Documentation: How do language style and content of clinical notes change when they are shared with patients as Open Notes? Module D - Optimization through Artificial Intelligence: Can clinical notes be processed using artificial intelligence in a way that makes them easier for patients to understand compared to conventional medical documentation? Module E - Integration into National Data Infrastructure: What technical, organizational and legal requirements must be met to successfully integrate Open Notes into the national telematics infrastructure and the electronic health record or routine care? The overall goal is to identify both patient-related outcomes and structural conditions for the sustainable implementation of Open Notes in the German healthcare system. The use of artificial intelligence is intended to further enhance patient-centeredness while reducing the burden on clinical staff.

Participants needed: 1,092
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Julian SchwarzUpdated: Aug 22, 2025
Eligibility criteria

Aged 18 years or older [+16]

Insufficient German language skills [+7]

Status: Recruiting

Eligibility of Patients Referred to Emergency Departments by Their General Practitioners for Care in Walk-in Clinics: A Single-Center Study in Île-de-France

This study aims to find out how many patients sent to the emergency department by their general practitioner could instead be treated in a walk-in clinic. Walk-in clinics provide quick, basic medical care without an appointment and can perform simple tests like blood work and X-rays. By identifying patients who don't need full hospital emergency care, this study hopes to improve patient flow and reduce overcrowding in emergency rooms in the Île-de-France region.

Participants needed: 80
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Centre Hospitalier de GonesseUpdated: Aug 14, 2025Locations: 1
Eligibility criteria

Age 18 years or older [+5]

Patients under 18 years old (pediatric cases excluded) [+8]

Status: Recruiting

Assessing the Effectiveness of Heat Adaptation Digital Messages From Primary Care Providers to Their Patients on the Change in Behaviour for Heatwave-related Preparedness

Extreme heat events pose a significant health threat in Canada, as demonstrated by the 2021 heat wave that claimed over 600 lives in Western Canada. Most heat-related deaths occur indoors and are preventable. Primary care providers (PCPs), who serve 88% of Canadians, are uniquely positioned to identify and support at-risk individuals. Heat Smart, in alignment with Heat Alert and Response Systems (HARS), aims to bridge the gap between primary care and public health to enhance community resilience and reduce health inequities related to extreme heat events. This randomized control trial in Eastern Ontario will examine whether patients receiving tailored digital health messages from their family physician or nurse practitioner change their behaviour to protect themselves from extreme heat-related illness. The Heat Smart study will: * Assess risk: Analyze electronic medical records and patient surveys to identify vulnerable individuals. * Deliver tailored messages: Send personalized digital guidance via e-mail or text, offering heat safety advice and local resource information in English and French. * Issue early warning alerts: Notify at-risk patients of upcoming heat events, prompting action. * Evaluate impact: Use surveys and health data to measure effectiveness in reducing heat-related health impacts. Short-term outcomes include increased awareness and preparedness among patients about heat-related health risks. Long-term goals involve scaling the intervention across Canada to reduce heat-related illnesses, enhance social connectedness, and decrease healthcare utilization.

Participants needed: 20,000
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Hopital MontfortUpdated: Jun 17, 2025Locations: 1
Eligibility criteria

Adults (18 years and older) [+13]

Status: Recruiting

Experiences of Anger in Patients in Primary Health Care With Symptoms of Generalized Anxiety

Symptoms of generalized anxiety is common in the general population and is often treated in primary health care. Anger is an emotion that can lead to interpersonal problems but can also be an agent for justice and change. Previous research has shown a link between generalized anxiety and anger but there is a lack of qualitative research investigating how individuals with symptoms of generalized anxiety experience anger. The aim of this research study is to increase knowledge about how anger is experienced in adult patients in primary health care with symptoms of generalized anxiety and about the experiences of health care professionals working with patients with symptoms of generalized anxiety.

Participants needed: 40
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Kronoberg County CouncilUpdated: Apr 16, 2025Locations: 1
Eligibility criteria

Clinically significant level of symptoms of generalized anxiety which is confirm... [+2]

Severe psychiatric difficulties where the patient needs specialized psychiatric... [+5]

Status: Recruiting

Impact of a Community-Based Primary Health Care Project on the Inappropriate Use of Emergency Medical System in Bergamo

The goal of this study is to reduce the inappropriate use of the Emergency Medical System in Bergamo. The main question it aims to answer is: can a Community-Based Primary Health Care Project impact on the use of the Emergency Medical System in Bergamo? Monthly changes in urgent calls to the Emergency Medical System will be analysed.

Participants needed: 10,000
Trial details
Age: Up to 100Biological sex: AllType: ObservationalSponsor: Fondazione San Giuliano OnlusUpdated: Mar 11, 2025Locations: 1
Eligibility criteria

Urgent Emergency Medical System call

Non-urgent Emergency Medical System call

Status: Recruiting

Report Cards and Feedback for PCCE

As part of UCLA Health's commitment to developing an integrated health system built on a foundation of physician-led, team-based primary care, the Department of Medicine (DOM) implemented a performance-based incentive plan called the Primary Care Clinical Excellence (PCCE) Incentive Plan. The UCLA Health DOM Quality team is leading the implementation and evaluation of this incentive plan across the UCLA Health primary care network, with the primary goal to immediately produce improvements in the quality of primary care. In order to rigorously measure the most efficacious ways to frame and communicate information about the quality improvement (QI) program, the DOM Quality team has partnered with the UCLA Anderson School of Management. Understanding the factors that motivate physicians to deliver high quality primary care will provide pivotal insights into the successful implementation of performance based programs nationwide.

Participants needed: 330
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of California, Los AngelesUpdated: Jan 30, 2025Locations: 1
Eligibility criteria

Primary care physicians within the UCLA Health Department of Medicine Primary Ca... [+2]

Physicians classified as Pediatrics will be excluded from data analysis given th... [+2]

Status: Recruiting

Options for Lowering the Threshold to Brussels Out-of-hours Primary Care Services for Dutch Speaking Citizens

The purpose of this qualitative study is to find out which technological translation tools can be used to improve Dutch-speaking care in all Brussels out-of-hours primary care services.

Participants needed: 40
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Universitair Ziekenhuis BrusselUpdated: Dec 27, 2024Locations: 1
Eligibility criteria

Patients: adult, living in Brussels, Dutch-speaking [+2]

Subject is not capable of will [+1]

Status: Not yet recruiting

Effect of HIFEM® Treatment of Urinary Incontinence in Women in Primary Care. A Randomized Controlled Trial

Urinary incontinence (UI) is a condition with involuntary leakage of urine. UI has a significant impact on health related quality of life, poorer sleep quality and sexual function, reduced participation in social and physical activities and is associated with large health care charge. Non-surgical method is always recommended as first action with a step-by-step care starting from non-invasive to more invasive interventions. Systematic overview shows that available non-surgical treatment options in primary care indicated low results in improving effect. HIFEM® technology is a non-invasive method and studies showed significant result on women with UI. For Swedish healthcare HIFEM® is a new medical technology product to treat UI. However, there is a lack of knowledge about the HIFEM® effect in women seeking primary care. The aim is to evaluate the effect of high-intensity electromagnetic energy (HIFEM®) on pelvic floor muscles, urinary leakage, sexual function, and health-related quality of life in women with urinary leakage in Swedish primary care, as well as to evaluate cost-effectiveness. The intervention included six 30 minutes HIFEM® sessions once a week over six weeks compared with control group. The results are expected to lead to effective non-surgical treatment options that can reach many patients, contribute to improving existing routines and can be a new potential way to support health promotion care in primary care and be a cost-effective investment.

Participants needed: 100
Trial details
Age: 40-70Biological sex: FemaleType: InterventionalSponsor: Vastra Gotaland RegionUpdated: Jul 3, 2024
Eligibility criteria

Woman [+3]

Woman with a serious illness such as psychosis, pulmonary insufficiency, epileps... [+16]

Status: Not yet recruiting

CRP and Lung Ultrasound in Respiratory Evaluation

Lower respiratory tract infections (LRTIs) are one of the most common reasons for consultation in Primary Care centres. Differentiating between viral and bacterial aetiologies can be challenging, leading to inappropriate antibiotic prescribing. Lung ultrasound (LUS), an imaging test that gained particular relevance since the beginning of the SARS-CoV-2 pandemic, offers several advantages over the classic chest X-ray in detecting and monitoring LRTIs, especially when pleural involvement exists. This study aims to correlate LUS findings with capillary blood C-Reactive Protein (CRP) values in patients with LRTIs, evaluating LUS as a diagnostic tool and its impact on therapeutic decisions. The descriptive observational study, conducted from January 2024 to December 2026 in Lleida, will include LRTI patients attending Primary Care centres. By validating LUS as a rapid and non-invasive diagnostic tool, unnecessary antibiotic prescriptions can be reduced, promoting LUS as a complementary test in Primary Care consultations. This will facilitate appropriate diagnosis and treatment decisions for patients with LRTIs, enhancing the overall management of respiratory infections.

Participants needed: 202
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Fundacio d'Investigacio en Atencio Primaria Jordi Gol i GurinaUpdated: Apr 30, 2024
Eligibility criteria

Age ≥ 18 years old [+2]

Patients who have been treated with antibiotics during the last 14 days up to in... [+5]

Status: Recruiting

Identification of Interpesonal Violence

The goal of this study is to increase primary care professional's ability to identify individuals exposed to intimate partner violence (IPV) in primary health care settings. The main questions it aims to answer are 1. To what extent do the following three interventions contribute to identify potential victims of IPV: (1) the use of a standardized questionnaire that screens exposure to IPV, (2) staff using tailored virtual patients for clinical training on IPV and (3) a combination of interventions 1 and 2? 2. Which intervention do primary care professionals experience as most effective in increasing the ability to identify and respond to victims of IPV? Participants will be divided to apply one of the three interventions in their health care setting: 1) a standardized questionnaire to patients, 2) virtual patients tailored to health professionals, and 3) a combination of 1 and 2. Pre-and post-measurement of the health professionals identification of patients exposed to IPV will will be used to explore the effect of the interventions. Focus group interviews with the participating health professionals will be a qualitative complement. The participants will be asked about what intervention they experience as the most effective in increasing the ability to identify victims of IPV.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Region StockholmUpdated: Apr 29, 2024Locations: 1
Eligibility criteria

All health care staff who meet patients at the included study sites are elegible... [+1]

Status: Recruiting

PrimeCog: Primary Care Cognitive Testing

The PrimeCog study aims to describe the symptomatology and pathophysiology of stress-induced exhaustion disorder (SED) and major depressive disorder (MDD) compared to healthy controls (HC). The participants will be recruited at primary care centers, and samples of blood, saliva, and hair will be collected. Digital questionnaires covering psychosocial variables and screening instruments for the detection of depression, anxiety, etc., along with a digital cognitive test battery, will be performed at home. Subsequently, an MRI of the brain will be performed, and analysis of biomarkers for stress, inflammation, and neurodegeneration will be conducted. These procedures will be repeated after twelve and twenty-four months. The study will investigate differences in the biomarkers, neuroimaging findings, and cognitive abilities between patients with SED, MDD, and controls over time. Associations between the symptom severity of MDD/SED and psychosocial variables, cognition, MRI, and the biomarkers will also be examined. The aim is to provide new diagnostic tools for differentiation between MDD and SED and guide individualized treatment based on underlying pathophysiology and cognitive function. All necessary competences for conducting this extensive study are represented within the research group. The PrimeCog study is unique in its comprehensive design, addressing knowledge gaps, and directly comparing these diagnoses over time in primary care, where patients are typically treated.

Participants needed: 300
Trial details
Age: 18-65Biological sex: AllType: ObservationalSponsor: Region ÖstergötlandUpdated: Apr 23, 2024Locations: 1
Eligibility criteria

adults 18 to 65 years old; [+3]

already ongoing treatment for MDD/SED or previous diagnosis of MDD/SED within th... [+6]

Status: Recruiting

The Effects of Primary Care Behavioral Health in Primary Care in Sweden

The novel multi-professional service delivery model "Primary Care Behavioural Health" (PCBH) has been suggested as an effective way to integrate behavioural health services into routine primary care to overcome the growing problems with psychosocial and mental health problems in primary care. In this multicenter mixed-methods pragmatic clinical trial, the implementation of PCBH in routine primary health care in a region in Sweden is investigated.

Participants needed: 500
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Region ÖstergötlandUpdated: Apr 23, 2024Locations: 1
Eligibility criteria

Adult patients who seek care for mental health problems at a participating centr... [+3]

Status: Not yet recruiting

Maternal Health Care and Pregnancy Outcomes in Undocumented Migrant Women in Norway.

Little research on the health service utilization and the health situation of undocumented pregnant migrants has been performed previously, and it is essential to obtain more information on the services given, and to examine whether residency status is a risk factor in maternal and perinatal health among migrants.This project will give new knowledge on undocumented women seeking care at the voluntary clinics and the emergency clinics (DEGPs) in Oslo and Bergen, their health care needs, and the medical follow-up they are provided. The project will present new knowledge by showing trends in undocumented pregnant migrants care seeking compared to general trends among other migrants and Norwegian residents. It will also give new knowledge on pregnancy outcomes and perinatal health in undocumented migrants compared to foreign and Norwegian born women. This approach has not previously been used to study undocumented migrants in Norway, and there are very few similar studies in other European countries. Cause and effect relations are rarely claimed in findings from observational epidemiologic studies, however the information from three different sources (voluntary clinics, emergency clinics and Medical Birth Registry) will give an overall picture of the use of primary health care in undocumented pregnant migrants, as well as a comparative assessment of maternal outcomes in this population. The proposed research will also give important knowledge on how to conduct quantitative research in a population that is difficult to reach, and that is not commonly included in research.

Participants needed: 70,000
Trial details
Age: 18-50Biological sex: FemaleType: ObservationalSponsor: University of OsloUpdated: Jun 25, 2020
Eligibility criteria

No registered Norwegian identity number [+1]

Male