Primary Mediastinal B-Cell Lymphoma

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Review clinical trials related to Primary Mediastinal B-Cell Lymphoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Neurocognitive Assessment in Long-Term Survivors of Lymphoma

This is an observational, multicenter, prospective cohort study including patients treated for lymphoma in Italian real-life. Patients eligible for the enrollment in the study will be consecutively included in Italian FIL centers. Patients will be evaluated once during regular follow-up, in the absence of clinical or radiologic signs of disease relapse. The assessment of neurocognitive functioning will be performed through a panel of tests, both self-administered and individually administered (about 1 hour). The administration of these neuropsychological tests should be done according to a standardized and predefined order. If available, according to local practice, a neuropsychologist may be involved in test administration and in the evaluation of the results. Based on its observational nature, no treatment change or modification or additional exams or visits will be required because of being enrolled in this study.

Participants needed: 100
Trial details
Age: 25-55Biological sex: AllType: ObservationalSponsor: Fondazione Italiana Linfomi - ETSUpdated: Jun 22, 2026Locations: 7
Eligibility criteria

Patients with previous diagnosis of classic Hodgkin Lymphoma (cHL) or Diffuse La... [+4]

Patients with CNS disease localization. [+2]

Status: Recruiting

Amping up With PemJAK

The purpose of this study is to understand and determine if ruxolitinib added to pembrolizumab is safe and effective for the treatment of relapsed or refractory Hodgkin and non-Hodgkin lymphomas.

Participants needed: 53
Trial details
Phase: Phase 2Age: 18-95Biological sex: AllType: InterventionalSponsor: Seda S. ToluUpdated: Dec 16, 2025Locations: 1
Eligibility criteria

Arm 1: PTCL [+41]

1) Diagnosis of Adult T-Cell Leukemia/Lymphoma (ATLL) [+17]

Status: Recruiting

Obinutuzumab and ICE Chemotherapy in Refractory/Recurrent CD20+ Mature NHL

The purpose of this study is to determine the safety of administering obinutuzumab as a single agent alone and in combination with ifosfamide, carboplatin, and etoposide (ICE) chemotherapy and determine the response rate of this treatment for children, adolescents and young adults (CAYA) with relapsed CD20 positive B-cell Non-Hodgkin Lymphoma (B-NHL).

Participants needed: 25
Trial details
Phase: Phase 2Age: 3-31Biological sex: AllType: InterventionalSponsor: New York Medical CollegeUpdated: Aug 8, 2025Locations: 1
Eligibility criteria

Diffuse Large B-Cell Lymphoma [+12]

Patients with newly diagnosed, previously untreated B-NHL. [+5]

Status: Recruiting

Study in Patients With Relapsed/Refractory Primary Mediastinal Lymphoma Treated With Pembrolizumab or Nivolumab in Combination With Brentuximab Vedotin in a Real-life Context

Observational, Non-Interventional, Retrospective, Multicenter Study Focusing on the Efficacy and Safety of Pembrolizumab Monotherapy and Nivolumab in Combination With Brentuximab Vedotin in Clinical Practice Patients With Primary Mediastinal B Cell Lymphoma Relapsed/Refractory

Participants needed: 50
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: IRCCS Azienda Ospedaliero-Universitaria di BolognaUpdated: Jan 30, 2025Locations: 3
Eligibility criteria

Histologically confirmed diagnosis of Primary Mediastinal B Cell Lymphoma Relaps... [+2]