Primary Teeth

4

Review clinical trials related to Primary Teeth. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial

The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and structural constraints directly impact treatment effectiveness. In these contexts, conventional pulpectomy using zinc oxide-eugenol (ZOE), although effective, may present operational limitations that restrict its large-scale applicability in public health systems. In this scenario, non-instrumental endodontic treatment (NIET), based on the concept of Lesion Sterilization and Tissue Repair (LSTR), has emerged as a simplified alternative. Among the available options, CTZ paste shows potential for single-visit application, reducing clinical time and technical complexity. This study aims to evaluate the clinical and radiographic non-inferiority of CTZ paste compared to conventional pulpectomy with ZOE in primary molars with pulp necrosis, with or without abscess or fistula, treated in emergency dental care settings. This is a randomized, pragmatic, controlled, non-inferiority clinical trial conducted at a single center, with clinical and radiographic follow-up at 3, 6, and 12 months. Participants will be allocated into two groups: (1) NIET with CTZ paste and (2) conventional pulpectomy with ZOE. Primary outcomes include pain resolution and absence of clinical signs of infection. Secondary outcomes include radiographic success, clinical time, child behavior (Frankl Scale), need for retreatment, and oral health-related quality of life. The findings are expected to provide robust evidence regarding the effectiveness of CTZ paste under real-world clinical conditions, contributing to the development of more accessible and effective protocols within public health systems, with the potential to expand access to conservative treatment and reduce early tooth extractions in pediatric dentistry.

Participants needed: 110
Trial details
Phase: Early Phase 1Age: 2-11Biological sex: AllType: InterventionalSponsor: University of Sao PauloUpdated: May 12, 2026
Eligibility criteria

Irreversible pulpitis in primary molars; [+4]

Reversible pulpitis; [+6]

Status: Not yet recruiting

Digital Occlusal Analysis and Bite Force Evaluation of Primary Molars Restored With Zirconia Crowns Using T-Scan

The goal of this observational study is to evaluate the adaptation of occlusion and bite force after zirconia crown restoration in children with pulp-treated primary molars. The main questions it aims to answer are: How does occlusion adapt after placement of zirconia crowns? Does bite force change following crown restoration? Participants will: Undergo routine pulp treatment and restoration of primary molars with zirconia crowns. Have bite force and occlusal contacts measured using the T-Scan digital occlusal analysis system before and after crown placement.

Participants needed: 11
Trial details
Age: 6-9Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Dec 11, 2025Locations: 1
Eligibility criteria

Children aged 6 to 9 years. [+7]

Children with medical conditions or who are uncooperative during dental care. [+6]

Status: Not yet recruiting

Comparison of 3Mixtatin Pulpotomy and Metapex Pulpectomy in Primary Molars With Irreversible Pulpitis

The present study aims to evaluate the clinical and radiographic success of pulpotomy using 3Mixtatin versus pulpectomy using Metapex in primary molars with irreversible pulpitis in children aged 4 to 9 years.

Participants needed: 50
Trial details
Phase: Phase 1Age: 4-9Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Apr 27, 2025
Eligibility criteria

Children aged from 4 to 9 years with vital primary molars showing signs of irrev... [+5]

Unrestorable primary molars. [+5]

Status: Recruiting

Zinc Oxide Ozonated Olive Oil in LSTR

This study will be carried out to evaluate and compare the clinical and radiographic effect of zinc oxide-ozonated olive oil (ZnO-OO) versus Modified Triple Antibiotic Paste (MTAP) as a Lesion Sterilization and Tissue Repair Technique in Primary Molars

Participants needed: 30
Trial details
Age: 4-7Biological sex: AllType: InterventionalSponsor: Tanta UniversityUpdated: Mar 3, 2025Locations: 2
Eligibility criteria

Widening of Periodontal ligament space. [+2]

Physiologic root resorption is more than one-third of its length. [+5]