PTSD (Childbirth-Related)

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Review clinical trials related to PTSD (Childbirth-Related). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

The New Empowerment After eXposure to Trauma (NEXT) Study

The NEXT Study is a randomized controlled pilot examining the feasibility and acceptability of a revised perinatal PTSD protocol. This study will randomize perinatal participants with PTSD to receive NET (n=45); treatment group) and will be compared to perinatal women randomized to usual care (n=45; comparator group). The overall objective of this project is to determine the most feasible and acceptable protocol for a brief virtual perinatal PTSD intervention.

Participants needed: 106
Trial details
Age: 18-50Biological sex: FemaleType: InterventionalSponsor: Indiana UniversityUpdated: Jun 18, 2026Locations: 1
Eligibility criteria

18 years of age or older [+3]

current severe suicide risk as determined by the Columbia Suicide Severity Ratin... [+7]

Status: Recruiting

Preventing Childbirth-Related PTSD With Expressive Writing

The goal of this clinical trial is to test a brief psychological intervention given to individuals in the first days following childbirth who have experienced a potentially stressful childbirth. The treatment is aimed at preventing post-traumatic stress disorder following childbirth and promoting maternal-infant bonding. In the days following childbirth, participants will be asked to write about their childbirth experience or a neutral event for three consecutive days, for around 15 minutes each day. Additionally, they will complete a short survey before and after the intervention about their birth experience and mental health. Around 2 months postpartum (with the option of up to around Month 3 PP), participants will take part in mental health and physiological assessments, and in a brief play session with their infant.

Participants needed: 136
Trial details
Age: 18-50Biological sex: FemaleType: InterventionalSponsor: Massachusetts General HospitalUpdated: May 22, 2026Locations: 1
Eligibility criteria

Women who recently delivered at Massachusetts General Hospital (MGH). [+1]

Age <18 or >50. [+10]

Status: Recruiting

Early Intervention for Postpartum PTSD: Comparing Written Exposure and Capnometry-Guided Breathing Therapy

The purpose of this study is to examine two early interventions, Written Exposure Therapy and Capnometry Guided Breathing, to reduce post-traumatic stress disorder (PTSD) symptoms in women after childbirth as compared to usual care.

Participants needed: 70
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Stanford UniversityUpdated: Apr 24, 2026Locations: 2
Eligibility criteria

Age ≥18 [+5]

Active psychosis or mania [+3]

Status: Not yet recruiting

Perioperative Dexmedetomidine to Reduce Post-procedure Grief Following Second-trimester Dilation and Evacuation

People seeking second-trimester dilation and evacuation (D\&E) procedures are often facing profoundly challenging circumstances, including desired pregnancies complicated by fetal anomalies or demise, serious maternal health conditions, or changes in financial or relationship status. Although abortion regret is uncommon, the emotional burden surrounding these experiences is substantial: many patients experience significant grief and post-traumatic stress symptoms in the weeks to months following care. Perioperative interventions that decrease the body's stress response offer a promising opportunity to reduce downstream psychologic morbidity. Dexmedetomidine has been shown to reduce PTSD symptoms in other high-stress medical and surgical settings. The investigators are undertaking a randomized trial to evaluate whether perioperative administration of dexmedetomidine during second-trimester D\&E can reduce the frequency and severity of post-procedural grief, directly addressing an unmet need in patient-centered, trauma-informed abortion care.

Participants needed: 100
Trial details
Phase: Phase 2, Phase 3Age: 18+Biological sex: FemaleType: InterventionalSponsor: Stanford UniversityUpdated: Apr 17, 2026Locations: 1
Eligibility criteria

English- or Spanish-fluency [+2]

Unscheduled or emergent procedure [+2]

Status: Recruiting

Feasibility and Efficacy of GTEP for Birth Trauma

This clinical study aims to evaluate the feasibility and initial efficacy of Group Traumatic Episode Protocol (GTEP) for reducing trauma symptoms (measured by the PCL-5 and City BiTS) for individuals following a traumatic birthing experience. A secondary aim is to evaluate the efficacy of GTEP in improving parental wellbeing (measured through the CORE-10) and parent-infant bonding (measured through the PBQ) following a traumatic birthing experience. Participants (those who have experienced a traumatic birthing experience) will complete the GTEP intervention, delivered online. They will be asked to complete outcome measures and give feedback on their experience of the group.

Participants needed: 10
Trial details
Age: 18-65Biological sex: FemaleType: InterventionalSponsor: University of BirminghamUpdated: Feb 19, 2026Locations: 1
Eligibility criteria

Aged between 18-65 years. [+7]

Women/birthing people whose baby is no longer under their care. [+2]