Status: Recruiting
ATORvastatin in Pulmonary TUBerculosis: a POPulation PharmacoKinetics -PharmacoDynamics Sub-study (ATORTUB popPK-PD)
The purpose of this study is to assess pharmacokinetic parameters of atorvastatin at different doses when combined with the standard first line tuberculosis (TB) treatment regimen in adults with drug sensitive pulmonary TB. The pharmacokinetics parameters will be correlated with Pharmcodynamic measures and a PK/PD model that will identify an optimal dosing regimen of atorvastatin that is appropriate for the treatment of pulmonary tuberculosis will be developed.
Participants needed: 80
Trial details
Phase: Phase 2Age: 12+Biological sex: AllType: InterventionalSponsor: Obafemi Awolowo University Teaching HospitalUpdated: Jan 23, 2026Locations: 3
Eligibility criteria
Sputum specimen positive for tubercle bacilli on Gene Xpert or direct smear micr... [+11]
Participants known or suspected of having any form of drug resistance TB. [+19]