Recurrent and Refractory Diffuse Large B-cell Lymphoma

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Review clinical trials related to Recurrent and Refractory Diffuse Large B-cell Lymphoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase III Clinical Study of Purinostat Mesylate for Injection in Patients With Diffuse Large B-cell Lymphoma

The main objective of this study is to evaluate the differences in objective response rate and overall survival between the Purinostat mesylate for injection and selinexor, as assessed by blinded independent central review (BICR), in patients with relapsed or refractory diffuse large B-cell lymphoma. .The participants in the experimental group will receive treatment with Purinostat mesylate for injection. The dosage is 11.2 mg/m2. Each administration cycle consists of intravenous administration on days 1, 4, 8, and 11. A 21-day period constitutes one treatment cycle, and the total treatment cycle lasts for 6 cycles. .Participants in the control group will receive selinexor treatment. The recommended dose is 60 mg per dose, taken orally on days 1 and 3 of each week (for example, Monday and Wednesday, or Tuesday and Thursday), and a 4-week period constitutes one treatment cycle.

Participants needed: 390
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Chengdu Zenitar Biomedical Technology Co., LtdUpdated: Sep 19, 2025Locations: 1
Eligibility criteria

Age ≥ 18 years, no gender restrictions; [+4]

Pregnancy or breastfeeding; [+4]