Reflux

2

Review clinical trials related to Reflux. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

The Mechanism Versus PPI Trial

The goal of this clinical trial is to learn if a mechanism guided strategy that utilizes a multidisciplinary approach to treat adults patients (age 18-89) with chronic throat symptoms who are undergoing clinical evaluation for laryngopharyngeal reflux (LPR) is more effective than the usual care strategy with proton pump inhibitor (PPI) therapy used in gastroenterology for these patients. The main question it aims to answer is: Will a greater proportion of the mechanism guided strategy participants achieve symptom response in comparison to the usual care strategy participants? If there is a comparison group: Researchers will compare the mechanism guided strategy to usual care strategy to see if treatment response differs between the groups. Participants will be be asked to do the following: * participate in an 8-week blinded study phase where they will be randomized to either 1) Mechanism Guided Strategy or 2) Usual Care Strategy * take an oral capsule daily (omeprazole 40mg or placebo) * come to 3 in-person visits at UC San Diego Health for an intervention visit with a study provider * consider incorporating recommended lifestyle modifications * complete weekly surveys

Participants needed: 160
Trial details
Phase: Phase 4Age: 18-89Biological sex: AllType: InterventionalSponsor: University of California, San DiegoUpdated: Aug 1, 2025Locations: 1
Eligibility criteria

18-89 years of age [+3]

PPI intolerance and/or known hypersensitivity to the formulation or substituted... [+14]

Status: Recruiting

The Role of Laryngopharyngeal Reflux in IPF

The primary objective of this study is to show that the Supraglottic Index (SGI) is an easily-collected index that accurately identifies the presence and severity of laryngopharyngeal reflux (LPF) in idiopathic pulmonary fibrosis (IPF).

Participants needed: 60
Trial details
Age: 40-95Biological sex: AllType: ObservationalSponsor: National Jewish HealthUpdated: Nov 14, 2024Locations: 1
Eligibility criteria

Diagnosis of IPF [+3]

Patients who do not meet all inclusion criteria [+1]