Health Trials

Refractory Sarcoma

1

Review clinical trials related to Refractory Sarcoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

This research is being done to test a new drug called PEEL-224 in combination with two commercially available drugs, Vincristine and Temozolomide, and to determine how effective this combination of drugs is at treating Ewing Sarcoma (EWS) and Desmoplastic Small Round Cell Tumor (DSRCT), as well as multiple other kinds of sarcomas. The names of the study drugs and biological agents involved in this study are: * PEEL-224 (a type of Topoisomerase 1 inhibitor) * Vincristine (A type of vinca alkaloid) * Temozolomide (A type of alkylating agent) * Pegfilgrastim or Filgrastim (types of Myeloid growth factors)

Participants needed: 63
Trial details
Phase: Phase 1, Phase 2Age: 12-49Biological sex: AllType: InterventionalSponsor: David S Shulman, MDUpdated: Feb 19, 2026Locations: 3
Eligibility criteria

Evaluable or measurable disease; and [+39]

Patients who have received prior treatment with PEEL-224. [+8]

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