Health Trials

Relapsed Leukemia

2

Review clinical trials related to Relapsed Leukemia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Roginolisib (IOA-244) With Venetoclax and Rituximab for Refractory/Relapsed Chronic Lymphocytic Leukemia (CLL)

This research study will test the safety and anticancer activity of the combination of three drugs (Roginolisib, Venetoclax, and Rituximab) for participants with relapsed or refractory Chronic Lymphocytic Leukemia (CLL). The names of the study drugs involved in this study are: * Roginolisib (a novel type of PI3-kinase delta inhibitor) * Venetoclax (a type of B-cell lymphoma 2 inhibitor) * Rituximab (a type of monoclonal antibody)

Participants needed: 64
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Jennifer R. Brown, MD, PhDUpdated: Feb 11, 2026Locations: 1
Eligibility criteria

Patients with relapsed/refractory CLL who meet iwCLL criteria for requiring trea... [+20]

Patients who have received prior treatment with venetoclax or PI3K inhibitors in... [+22]

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Status: Recruiting

Phase 1 Study of Chemotherapy Plus HLA-mismatched GPBMC Infusion Bridging to Allo-HSCT for R/R Leukemia

This is a Phase 1 clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of chemotherapy combining with HLA-mismatched G-CSF mobilized peripheral blood mononuclear cell (GPBMC) infusion as a bridging therapy to allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with relapsed and refractory (R/R) leukemia.

Participants needed: 5
Trial details
Phase: Phase 1Age: 15+Biological sex: AllType: InterventionalSponsor: Beijing 302 HospitalUpdated: Dec 22, 2025Locations: 1
Eligibility criteria

Age >=15 years, male or female, non-limited by race or ethnicity. [+6]

Uncontrolled infection or hemorrhage. [+7]

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