Relapsed or Refractory Hematologic Malignancies

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Review clinical trials related to Relapsed or Refractory Hematologic Malignancies. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Safety and Efficacy of DIT101 in Relapsed or Refractory Hematologic Malignancies

This study is a single-arm, open-label clinical trial designed to evaluate the safety and tolerability of DIT101 in adults with relapsed or refractory hematologic malignancies and to explore its potential anti-tumor effects. DIT101 is an investigational in vivo CAR-T cell therapy administered by intravenous infusion. After administration, it is intended to generate CAR-T cells within the patient's body that can recognize and attack tumor cells. Unlike approved autologous CAR-T therapies, DIT101 does not require collection and ex vivo genetic modification of the participant's own cells. The study includes a screening period, DIT101 infusion treatment, a post-treatment intensive follow-up period of approximately 6 months, and a long-term follow-up period of up to 2 years, with visits every 3-6 months.

Participants needed: 15
Trial details
Phase: Phase 1Age: 18-70Biological sex: AllType: InterventionalSponsor: Tcelltech Inc.Updated: Mar 20, 2026Locations: 1
Eligibility criteria

Adults aged 18 to <70 years, any gender. [+17]

Pregnant or breastfeeding women. [+23]

Status: Recruiting

Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies

The aim of this study is to investigate the safety and tolerability of trichostatin A in individuals with relapsed or refractory hematologic malignancies.

Participants needed: 42
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Vanda PharmaceuticalsUpdated: Mar 16, 2026Locations: 11
Eligibility criteria

Subject is ≥ 18 years at the time of signing informed consent; [+4]

Allogeneic stem cell transplant recipient presenting with graft versus host dise... [+5]

Status: Recruiting

A Phase I Study of QLS2309 Injection in Patients With CD70+ Relapsed/Refractory Hematologic Malignancies

This is a single-arm, open-label, multicenter, dose-escalation, dose-expansion and efficacy-expansion phase I clinical study to evaluate the tolerability, safety, pharmacokinetics and preliminary antitumor activity of QLS2309 injection in patients with CD70+ relapsed/refractory hematologic malignancies.

Participants needed: 186
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Qilu Pharmaceutical Co., Ltd.Updated: Jan 2, 2026Locations: 1
Eligibility criteria

1. Subjects voluntarily participated and signed a written informed consent form [+7]

Prior treatment with CD70-related antibodies, antibody-conjugated drugs (ADCs) o... [+5]

Status: Not yet recruiting

A Clinical Study of BT02 in Patients With Relapsed or Refractory Hematologic Malignancies

The goal of this clinical trial is to learn about the safety, tolerability and preliminary effectiveness of a treatment for patients with relapsed or refractory hematologic malignancies, regardless of gender, aged between 18(inclusive) and 70 years . Participants will receive the investigational product intravenously every two or three weeks. The treatment will continue for a maximum of two years for those who do not show signs of disease progression or experience intolerable side effects.

Participants needed: 116
Trial details
Phase: Phase 1, Phase 2Age: 18-70Biological sex: AllType: InterventionalSponsor: Biotroy TherapeuticsUpdated: Sep 17, 2025
Eligibility criteria

Voluntary participation with signed informed consent by the participant or their... [+9]

Acute promyelocytic leukemia (APL). [+16]

Status: Recruiting

A Clinical Study of SCTC21C in Participants With CD38+ Hematologic Malignancies

The purpose of this study is to evaluate the safety and efficacy of SCTC21C in patients with CD38+ hematologic malignancies

Participants needed: 74
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Sinocelltech Ltd.Updated: Apr 22, 2024Locations: 1
Eligibility criteria

Male or female aged ≥ 18 years old when signing ICF, weight ≥ 40 kg, ≤ 90 kg [+8]

A history of allergic reactions to any SCTC21C injection or any excipients, or P... [+15]