Health Trials

Relapsed Refractory Acute Lymphoblastic Leukemia

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Review clinical trials related to Relapsed Refractory Acute Lymphoblastic Leukemia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

CD19 Chimeric Antigen Receptor (CAR) T Cells in Adults With Relapsed/Refractory CD19 Positive Acute Lymphoblastic Leukemia

This is a Phase Ia, open label, dose finding single center trial designed to evaluate the maximum tolerated dose, safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of CD19 CAR T cells targeting the B cell surface antigen CD19 following administration of chemotherapy lymphodepletion regimen in adults (age 18 - 75) with relapsed/refractory acute lymphoblastic leukemia (ALL).

Participants needed: 24
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: King Faisal Specialist Hospital & Research CenterUpdated: Jan 22, 2026Locations: 1
Eligibility criteria

Second or greater bone marrow (BM) relapse; or [+10]

Clinically Active central nervous system (CNS) involvement by malignancy [+31]

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