Relapsed/Refractory B-cell Malignancies

8

Review clinical trials related to Relapsed/Refractory B-cell Malignancies. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

A Study of the LVIVO-TaVec122 Product in Subjects With Relapsed/Refractory B-cell Malignancies

This is a single-arm, open-label and dose-escalation clinical study to evaluate the LVIVO-TaVec122 product in adult subjects with Relapsed/Refractory B-cell Malignancies.

Participants needed: 48
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: The First Affiliated Hospital with Nanjing Medical UniversityUpdated: Jun 5, 2026Locations: 1
Eligibility criteria

Subjects voluntary agreement to provide written informed consent. [+6]

Prior antitumor therapy with insufficient washout period. [+5]

Status: Recruiting

IASO208 Injection in the Treatment of Relapsed/Refractory B-cell Malignancies

This is an investigator-initiated, single-arm, open-label clinical study. It employs a dose-escalation design to evaluate the safety, pharmacokinetics, and preliminary efficacy of IASO208 injection in relapsed/refractory B-cell malignancies.

Participants needed: 12
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyUpdated: Jun 1, 2026Locations: 1
Eligibility criteria

Aged ≥18 years and ≤75 years. [+20]

Subjects with central nervous system involvement. [+22]

Status: Recruiting

The CD19/CD20 Dual-Target in Vivo CAR-T Lentiviral Product in the Treatment of Relapsed/Refractory B-cell Malignancies

A Phase I Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of the CD19/CD20 Dual-Target in vivo CAR-T Lentiviral product in the Treatment of Relapsed/Refractory B-cell Malignancies.

Participants needed: 30
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: The First Affiliated Hospital with Nanjing Medical UniversityUpdated: May 14, 2026Locations: 6
Eligibility criteria

Subjects voluntarily participate in clinical studies; Fully informed of this stu... [+7]

Prior antitumor therapy with insufficient washout period ; [+4]

Status: Not yet recruiting

Phase I Clinical Study to Evaluate SYS6055 Injection in Participants With Relapsed/Refractory B-Cell Malignancies

(Limit: 5000 characters) The purpose of this phase I clinical study aims to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of SYS6055 Injection in participants with relapsed/refractory B-cell malignancies, and to provide evidence for recommending a dosage regimen for subsequent studies.

Participants needed: 86
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Institute of Hematology & Blood Diseases Hospital, ChinaUpdated: Apr 15, 2026
Eligibility criteria

Age≥18 year, and voluntarily signed the Informed Consent Form (ICF); [+8]

History of other malignancy within 3 years or concurrent other active malignancy... [+20]

Status: Recruiting

Clinical Study Evaluating the Safety and Efficacy of BAFFR CAR-T Therapy for Relapsed/Refractory B-cell Malignancies

This is a prospective, single-arm, multi-center, randomized controlled clinical study designed to evaluate the safety and efficacy of BAFFR CAR-T therapy for relapsed/refractory B-cell malignancies. A total of 30 subjects are planned to be enrolled.

Participants needed: 28
Trial details
Age: 18-78Biological sex: AllType: InterventionalSponsor: Donghua ZhangUpdated: Jan 16, 2026Locations: 1
Eligibility criteria

Alanine transaminase (ALT) ≤ 3 × upper limit of normal (ULN); [+6]

Corticosteroids: Subjects receiving systemic steroid therapy within 2 weeks prio... [+1]

Status: Recruiting

Safety and Efficacy of ZZSW-01 in Relapsed/Refractory B-cell Malignancies

This is a single-center, single-arm, open-label, dose-escalation, early-phase 1 study to evaluate the safety, tolerability and preliminary efficacy of ZZSW-01 injection in patients with relapsed/refractory B-cell malignancies.

Participants needed: 6
Trial details
Phase: Early Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyUpdated: Nov 21, 2025Locations: 1
Eligibility criteria

Age ≥18 years, no restriction on sex. [+6]

Patients with CNS involvement of B-cell malignancies confirmed by lumbar punctur... [+35]

Status: Recruiting

UBX-303061 in Subjects With Relapsed/Refractory B-Cell Malignancies

This is a first-in-human Phase 1a/1b multicenter, open-label study designed to evaluate the safety and anti-cancer activity of UBX-303061 in patients with relapsed/refractory B-cell malignancies.

Participants needed: 94
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Ubix Therapeutics, Inc.Updated: Nov 19, 2025Locations: 11
Eligibility criteria

Capable of giving signed informed consent [+6]

Systemic antineoplastic therapy or any experimental therapy within 3 weeks or 5... [+15]

Status: Recruiting

A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies

This clinical trial is evaluating a drug called AC676 in participants with Relapsed/Refractory B-cell Malignancies. The main goals of the study are to: * Identify the recommended dose of AC676 that can be given safely to participants * Evaluate the safety profile of AC676 * Evaluate the pharmacokinetics of AC676 * Evaluate the effectiveness of AC676

Participants needed: 60
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Accutar Biotechnology IncUpdated: Oct 2, 2025Locations: 9
Eligibility criteria

Adult male and female patients, at least 18 years-of-age at the time of signatur... [+2]

Small molecule anti-cancer drugs within 5 half-lives or 2 days (whichever is lon... [+8]