Health Trials

Ropeginterferon

1

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Condition / disease
Location
Status: Not yet recruiting

A Phase 1b/2 Study of Ropeginterferon Alfa-2b Added to Azacitidine in Newly Diagnosed MDS/AML (≥ 10% Blasts) With TP53 Mutations

To find the recommended dose of ropeginterferon alfa-2b in combination with azacitidine in patients with newly diagnosed MDS/AML with TP53 mutations. To learn if the recommended dose of ropeinterferon alfa-2b found in Dose Escalation in combination with azacitidine can help to control the disease.

Participants needed: 30
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: M.D. Anderson Cancer CenterUpdated: Jun 15, 2026Locations: 1
Eligibility criteria

Single TP53 mutation> 10% VAF [+25]

Adult participants with MDS/AML without a known pathogenic TP53 mutation [+13]

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