RTT

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Review clinical trials related to RTT. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Neurophysiologic Biomarkers in Rett Syndrome

The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinical changes in individuals with RTT? * Are biomarkers stable over time in clinically stable individuals? * Do these biomarkers correlate with severity of RTT? Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity in the brain. Researchers will compare findings in individuals with RTT to those in typically developing individuals to see if there are differences between the two groups.

Participants needed: 202
Trial details
Age: 1-18Biological sex: FemaleType: ObservationalSponsor: Children's Hospital of PhiladelphiaUpdated: Oct 20, 2025Locations: 6
Eligibility criteria

Rett Group: Females ages 3-18 (inclusive) with a clinical diagnosis of RTT with... [+2]

Presence of a duplication in MECP2 or any other identified pathogenic mutation i... [+4]