Status: Recruiting
Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients
This is a cohort study aimed at developing a stratified medicine approach for personalised neoadjuvant chemotherapy (NCT) in high-risk soft tissue sarcoma (STS) patients with dedifferentiated liposarcoma (DDLPS), leiomyosarcoma (LMS), synovial sarcoma (SS), vascular sarcomas, malignant peripheral nerve sheath tumour (MPNST) or other subtypes. It comprises of both retrospective and prospective tissue collection from patients advancing directly to surgery (control group) and patients receiving NCT and surgery.
Participants needed: 800
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Royal Marsden NHS Foundation TrustUpdated: Feb 25, 2026Locations: 1
Eligibility criteria
Written informed consent for the prospective cohort [+12]
Known additional malignancy that is progressing or requires active treatment [+2]