Sellar Tumor

2

Review clinical trials related to Sellar Tumor. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Efficacy and Safety Evaluation of Absorbable and Moldable Skull Base Support Plates in Extended Endoscopic Endonasal Transsphenoidal Surgery: A Prospective, Randomized, Controlled Study

Primary objective: To evaluate the effect of absorbable and moldable skull base support plates used in extended endoscopic endonasal transsphenoidal surgery on the incidence of cerebrospinal fluid (CSF) rhinorrhea within 1 month after surgery. Secondary objectives: 1. To evaluate the effect of absorbable and moldable skull base support plates used in extended endoscopic endonasal transsphenoidal surgery on the incidence of intracranial infection within 1 months after surgery; 2. To evaluate the effect of absorbable and moldable skull base support plates used in extended endoscopic endonasal transsphenoidal surgery on the duration of the surgery and length of postoperative hospital stay; 3. To monitor and evaluate the safety of absorbable and moldable skull base support plates, especially the occurrence of nasal complications.

Participants needed: 126
Trial details
Phase: Phase 2Age: 1-80Biological sex: AllType: InterventionalSponsor: Nanfang Hospital, Southern Medical UniversityUpdated: Apr 20, 2026Locations: 8
Eligibility criteria

Aged 1-80 years, regardless of gender; [+5]

Patients with other concurrent intracranial tumors or severe brain lesions; [+8]

Status: Not yet recruiting

Optic Nerve Stimulation To Prevent Visual Deficits After Endoscopic Cranial Approaches

Assessing the function of the optic nerve is paramount during various neurosurgical procedures. Effective optic nerve monitoring has remained elusive as Visual Evoked Potentials (the current existing tool) provides only diffuse and delayed assessment of nerve function. Here, the investigators propose a prospective study involving adult patients (aged 18 years and older) undergoing endonasal or open cranial approaches around the optic nerves, who will receive pre- and post-operative visual evaluations. During surgery, the optic nerve and chiasm will be stimulated, and the response will be recorded in both eyes and the occipital cortex via skin electrodes. The investigators aim to utilize anterograde optic nerve microstimulation to assess the nerve's integrity during open and endoscopic cranial approaches. Electrophysiological readings will be acquired, as is routine in the operating room, by our team of experts, and intraoperative findings will be correlated with post- surgical clinical outcomes. Our objective is to utilize existing technology in the operating room to safely and effectively monitor optic nerve function during surgery.

Participants needed: 20
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of California, San FranciscoUpdated: Jul 12, 2024Locations: 1
Eligibility criteria

Patients diagnosed with suprasellar tumors including meningiomas, craniopharyngi... [+2]

Preexisting visual impairments unrelated to the tumor. [+5]