Semantic Variant Primary Progressive Aphasia (svPPA)

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Review clinical trials related to Semantic Variant Primary Progressive Aphasia (svPPA). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Intervention for Communication Quality of Life in Primary Progressive Aphasia

The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and/or Spanish. The main questions the study aims to answer are: * Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners? * Do participants with PPA and study partners find treatment beneficial? * What patterns of treatment response are seen in participants? * Which outcome measures are most useful for evaluating changes in communication and quality of life? Researchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life. Participants will: * Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period. * Receive education and communication training together with their partner. * Complete speech, language, and cognitive assessments. * Complete questionnaires about communication abilities, daily functioning, and quality of life.

Participants needed: 30
Trial details
Age: 40+Biological sex: AllType: InterventionalSponsor: Maya HenryUpdated: Apr 21, 2026Locations: 1
Eligibility criteria

A PPA (Gorno-Tempini et al., 2011) or "PPA-plus" (Mesulam et al., 2001) diagnosi... [+7]

Other central nervous system or medical diagnosis that can account for symptoms [+1]

Status: Recruiting

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD for 2019 and beyond.

Participants needed: 2,100
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Mayo ClinicUpdated: Jul 11, 2025Locations: 27
Eligibility criteria

members of families in whom at least one member has a known disease-associated m... [+7]

Known presence of a structural brain lesion (e.g. tumor, cortical infarct) that... [+5]