Health Trials

Severe Hypertriglyceridemia (sHTG)

2

Review clinical trials related to Severe Hypertriglyceridemia (sHTG). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

CS-121 APOC3 Base Editing in Severe Hypertriglyceridemia

This is an open-label, single-arm, dose-escalation IIT clinical trial to evaluate the safety, tolerability, pharmacodynamics (PD), and pharmacokinetics (PK) of CS-121, an in vivo base editing therapy delivered by lipid nanoparticles targeting APOC3, in adult participants (18-65 years) with Severe Hypertriglyceridemia(sHTG).

Participants needed: 15
Trial details
Phase: Early Phase 1Age: 18-65Biological sex: AllType: InterventionalSponsor: CorrectSequence Therapeutics Co., LtdUpdated: Jun 18, 2026Locations: 1
Eligibility criteria

Male or female participants aged 18 years ≤ age < 65 years. [+4]

Currently participating in other interventional clinical studies, or having an i... [+18]

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Status: Recruiting

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

This is a single-arm, open-label, multicenter, ascending dose Phase 1 trial that will enroll participants 18 to 75 years of age with dyslipidemias that are refractory to available treatments.

Participants needed: 90
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: CRISPR Therapeutics AGUpdated: May 22, 2026Locations: 18
Eligibility criteria

Age of ≥18 and ≤75 years at the time of signing the informed consent. [+5]

Participants with familial chylomicronemia syndrome (FCS). Some exceptions may a... [+6]

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