Soft Tissue Injuries

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Review clinical trials related to Soft Tissue Injuries. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

IASTM Effects on Pain, Functionality, and Proprioception in Subacromial Impingement

The aim of this study will be to investigate the effects of Instrument-Assisted Soft Tissue Mobilization (IASTM), applied in addition to a conventional exercise program, on pain, range of motion, proprioception, functionality, and quality of life in individuals with Subacromial Impingement Syndrome (SIS).

Participants needed: 38
Trial details
Age: 40-60Biological sex: AllType: InterventionalSponsor: Istanbul Medipol University HospitalUpdated: Mar 25, 2026Locations: 1
Eligibility criteria

Individuals diagnosed with SIS by MRI [+3]

Individuals with a history of surgery on the affected arm [+4]

Status: Not yet recruiting

Resurfacing of Foot and Distal Leg Soft Tissue Defects Using Reversed Pedicled Peroneal Artery Flaps Augmented by Superficial Sural Artery

Wounds involving the skin and soft tissue of the lower leg, ankle, heel, and foot can be difficult to treat because there is very little skin and tissue available in that area to cover the wound. When the wound is large or involves exposed bone or tendon, a flap, which is a piece of skin and tissue moved from a nearby area, is needed to close it. This study evaluates a surgical technique called the Reversed Peroneal Artery Flap (RPAF). In this procedure, a flap of skin and tissue from the outer side of the lower leg is lifted and rotated to cover the wound. The blood supply to the flap comes from the peroneal artery, which runs along the fibula bone, and is augmented by the superficial sural artery to improve flap survival. The study will include 30 adult patients who have soft tissue defects of the distal leg, ankle, heel, or foot. All patients will undergo the RPAF procedure at Assiut University Hospitals, Egypt. The main goal is to measure how well the flap survives after surgery. Secondary goals include assessing complications, functional recovery, and the condition of the donor site.

Participants needed: 30
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Assiut UniversityUpdated: Mar 5, 2026
Eligibility criteria

Patients with soft tissue defects of the distal third of the leg, ankle, heel, o... [+3]

Patients with peripheral vascular disease (PVD) or diabetes mellitus (DM) or smo... [+2]

Status: Recruiting

Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children

Local anaesthesia is considered one of the most alarming and non-comfortable dental procedures for children. This goes back to the persisting effect of the local anaesthesia after finishing dental procedures. The effect of Local anaesthesia can last from 3 to 5 hours due to the presence of vasoconstrictor. The U.S Food and Drug Administration (FDA approved the use of phentolamine mesylate (Oraverse) in May 2008 to be used as a drug in reversing the numbing effect of Local anaesthesia by decreasing the time needed to restore the normal functions of the mouth

Participants needed: 100
Trial details
Phase: Phase 3Age: 5-7Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Jul 10, 2025Locations: 1
Eligibility criteria

Patients in need of dental procedures requiring local anaesthesia. [+3]

Children seeking dental treatment that does not necessitate local anaesthesia. [+3]

Status: Recruiting

A Cross-Sectional Observational Study on Retained Drug Needle Fragments in People Who Use Intravenous Drugs

In addition to the well-known toxicological harms of intravenous drug (IVD) use, there can also be local tissue complications, including infections, venous sclerosis, tissue necrosis, and drug needle fragment retentions. Drug needle fragments in subcutaneous tissue may cause local symptoms (usually pain and infections), but they have also been identified as causing emboli to organs. The literature has described numerous case reports of people who inject drugs (PWIDs) and have retained needle fragments. The prevalence of the condition is not known, and the researchers therefore aim to perform the first cross-sectional study of PWIDs to estimate how common needle fragment retentions are and what their risk factors are in this population.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Tampere University HospitalUpdated: Jun 1, 2023Locations: 1
Eligibility criteria

History of intravenous drug use [+3]

No history of intravenous drug use [+3]