Health Trials

Systematic medIastinal Lymph Node Dissection

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Condition / disease
Location
Status: Not yet recruiting

Selective Mediastinal Lymph Node Sampling Versus Systematic medIastinal Lymph Node Dissection After Neoadjuvant Chemoimmunotherapy for Non-small Cell Lung Cancer (SCIENCE Study)

The SCIENCE trial is a multicenter, open-label, randomized, parallel, noninferiority investigator-initiated trial (IIT). This study aims to evaluate the prognostic differences between selective mediastinal lymph node sampling and systematic mediastinal lymph node dissection in patients with node-negative stage IIA to IIIB (N2) non-small-cell lung cancer (NSCLC) undergoing anatomical lobectomy following neoadjuvant chemoimmunotherapy.

Participants needed: 358
Trial details
Phase: Phase 3Age: 18-75Biological sex: AllType: InterventionalSponsor: Wen-zhao ZHONGUpdated: Jun 1, 2026Locations: 1
Eligibility criteria

Voluntary participation with a signed written informed consent form. [+11]

Anticipated inability to tolerate an anatomical lobectomy; [+14]

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