Health Trials

T-cell Large Granular Lymphocyte Leukemia

2

Review clinical trials related to T-cell Large Granular Lymphocyte Leukemia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study of Ruxolitinib and Duvelisib in People With Lymphoma

This study will test the safety of ruxolitinib, given at one dose that does not change, and duvelisib, given at different doses, to find out what effects, if any, the study treatment has on people with relapsed or refractory NK-cell or T-cell lymphoma. This study has three parts: dose escalation (Part 1), dose expansion (Part 2), and TFH/T-PLL cohort expansion (Part 3).

Participants needed: 70
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Memorial Sloan Kettering Cancer CenterUpdated: Apr 9, 2026Locations: 9
Eligibility criteria

Absolute neutrophil count ≥1.0 K/mcL (Note: growth factor is allowed) [+10]

Any serious medical condition, laboratory abnormality, or psychiatric illness th... [+8]

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Status: Recruiting

Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia

This phase II trial tests whether ruxolitinib works to shrink tumors in patients with T-cell large granular lymphocyte leukemia. Ruxolitinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Participants needed: 30
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Jonathan BrammerUpdated: Feb 10, 2026Locations: 3
Eligibility criteria

Age 18 or older and able to swallow pills [+17]

Absolute neutrophil count (ANC) less than 100/mm^3. Note: granulocyte colony-sti... [+9]

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