Health Trials

Telomere Biology Disorder

2

Review clinical trials related to Telomere Biology Disorder. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

This is a phase II trial of T cell receptor alpha/beta depletion (α/β TCD) peripheral blood stem cell (PBSC) transplantation in patients with inherited bone marrow failure (BMF) disorders to eliminate the need for routine graft-versus-host disease (GVHD) immune suppression leading to earlier immune recovery and potentially a reduction in the risk of severe infections after transplantation.

Participants needed: 48
Trial details
Phase: Phase 2Age: Up to 65Biological sex: AllType: InterventionalSponsor: Masonic Cancer Center, University of MinnesotaUpdated: Jan 30, 2026Locations: 1
Eligibility criteria

Diagnosis of Fanconi anemia [+14]

Pregnant or breastfeeding as the treatment used in this study are Pregnancy Cate... [+15]

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Status: Recruiting

Regenerative Medicine to Restore Hematopoiesis and Immune Function in Immunodeficiencies and Inherited Bone Marrow Failures

Phase II prospective trial to assess the rates of donor engraftment using reduced intensity conditioning (RIC) hematopoietic stem cell transplant (HSCT) and post-transplant cyclophosphamide (PTCy) for patients with primary immune deficiencies (PID), immune dysregulatory syndromes (IDS), inherited bone marrow failure syndromes (IBMFS), short telomere syndromes, Fanconi anemia, and non-Fanconi DNA double-strand break (DNA-dsb) repair disorder.

Participants needed: 27
Trial details
Phase: Phase 2Age: 4-50Biological sex: AllType: InterventionalSponsor: Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsUpdated: Nov 28, 2025Locations: 1
Eligibility criteria

Chronic granulomatous disease (CGD) [+35]

Patients will not be excluded on the basis of sex, racial or ethnic background. [+22]

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